Glycans of Schistosoma mansoni and keyhole limpet haemocyanin induce hepatic granulomas in vivo

International Journal for Parasitology
Koen K Van de VijverE A van Marck

Abstract

Schistosoma mansoni eggs trapped in the liver of an infected host cause the major pathological manifestations of schistosomiasis. Miracidia within the deposited eggs secrete soluble egg antigens (SEA) that induce periovular granuloma formation, which may lead to severe hepatic fibrosis. Several reports have highlighted the immunomodulatory capacities of carbohydrate determinants present in the glycoproteins of SEA. These glycans contain among others the immunogenic Galbeta1-4(Fucalpha1-3)GlcNAc (LewisX) and GalNAcbeta1-4(Fucalpha1-2Fucalpha1-3)GlcNAc (LDN-DF) elements. Due to cross-reactivity with schistosomal glycan antigens, keyhole limpet haemocyanin (KLH) has been used extensively for diagnostic and therapeutic studies on schistosomiasis. In the present study, a granulomatous response with numerous eosinophils towards SEA- and KLH-coated beads implanted in the liver by mesenteric injection was observed. Immunophenotyping of these experimentally induced granulomas for cellular recruitment, chemokines, adhesion and extracellular matrix proteins revealed very close resemblance with hepatic lesions evoked by native schistosome eggs, hence demonstrating the usefulness of the bead model, in general, as well as of KLH as a model a...Continue Reading

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Citations

Sep 6, 2005·Parasite Immunology·C H Hokke, M Yazdanbakhsh
Jul 31, 2007·Experimental Parasitology·Cornelis H HokkeManfred Wuhrer
Aug 16, 2011·Experimental Parasitology·Saskia deWalickJaap J van Hellemond
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Aug 13, 2021·Molecular Psychiatry·Paulo Sérgio de Almeida AugustoFrederico Duarte Garcia

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