Glycated albumin predicts the effect of dual and single antiplatelet therapy on recurrent stroke.

Neurology
Jiejie LiCHANCE Investigators

Abstract

To determine the relationship of glycated albumin (GA) and the recurrence of stroke in patients on either dual or single antiplatelet therapy. The Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events trial randomized minor ischemic stroke or TIA patients to antiplatelet therapy of clopidogrel plus aspirin or aspirin alone. A subgroup of 3,044 consecutive patients with baseline GA levels from 73 (64%) prespecified clinical sites was analyzed. Patients were categorized into 2 groups based on GA level of 15.5%, the cut point for development of diabetes. The primary outcome was stroke recurrence during 90-day follow-up. Cox proportional hazards models were used to assess the interaction of GA with randomized antiplatelet therapy on their risk of recurrent stroke. Significant interaction of GA levels with the 2 antiplatelet therapy groups was found after adjustment for age, sex, and other conventional confounding factors (p = 0.009). The interaction remained consistent after further adjustment for history of diabetes (p = 0.010). In patients with lower GA level, stroke occurred in 5.5% of patients in the clopidogrel-aspirin group, and 12.7% in the aspirin group (adjusted hazard ratio [HR] 0.40; 95% confid...Continue Reading

Citations

Aug 22, 2015·Current Cardiology Reports·Yilong WangYongjun Wang
Jun 3, 2016·Neuroscience Bulletin·Jiejie Li, Yongjun Wang
Jun 3, 2017·Journal of the American Heart Association·Weiqi ChenUNKNOWN CHANCE Investigators
Mar 5, 2019·Neuromolecular Medicine·Joseph Kamtchum-Tatuene, Glen C Jickling
Apr 12, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·X XieUNKNOWN CHANCE investigators
Oct 13, 2020·Journal of Clinical and Experimental Neuropsychology·Anastasia MatchanovaSteven Paul Woods
Jun 25, 2021·Neuroscience Bulletin·Jiejie LiYongjun Wang

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