Abstract
The American Diabetes Association recently included glycated hemoglobin in the diagnostic criteria for diabetes, but research on the utility of this biomarker in Southeast Asians is scant. The aim of this study was to evaluate the association between percent HbA1c and incident diabetes in an Asian population of adult men and women without reported diabetes. Data analysis of 5,770 men and women enrolled in the Singapore Chinese Health Study who provided a blood sample at the follow-up I visit (1999-2004) and had no cancer and no reported history of diabetes or cardiovascular disease events. Diabetes was defined as self-report of physician diagnosis, identified at the follow-up II visit (2006-2010). Hazard ratios (and 95% confidence intervals) for incident diabetes by 5 categories of HbA1c were estimated with Cox regression models and continuous HbA1c with cubic spline analysis. Compared to individuals with an HbA1c ≤ 5.7% (≤39 mmol/mol), individuals with HbA1c 5.8-5.9% (40-41 mmol/mol), 6.0-6.1% (42-43 mmol/mol), 6.2-6.4% (44-47 mmol/mol), and ≥ 6.5% (≥48 mmol/mol) had significantly increased risk for incident diabetes during follow-up. In cubic spline analysis, levels below 5.7% HbA1c were not significantly associated with inci...Continue Reading
References
Nov 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Randie R Little
Jan 17, 2004·Lancet·UNKNOWN WHO Expert Consultation
Dec 22, 2004·Journal of General Internal Medicine·David EdelmanEugene Z Oddone
Feb 3, 2005·Clinical Chemistry·Michael SteffesMaren Nowicki
Jun 28, 2006·Diabetes Care·Celine DroumaguetUNKNOWN DESIR Study Group
Nov 14, 2006·Lancet·Kun-Ho YoonHo-Young Son
Aug 7, 2007·The American Journal of Medicine·Aruna D PradhanPaul M Ridker
Oct 10, 2008·The American Journal of Clinical Nutrition·Andrew O OdegaardMimi C Yu
Jan 10, 2009·Diabetes Care·Kyoko Kogawa SatoHiroshi Kambe
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Feb 18, 2010·American Journal of Epidemiology·Andrew O OdegaardMark A Pereira
Mar 5, 2010·The New England Journal of Medicine·Elizabeth SelvinFrederick L Brancati
May 28, 2010·The New England Journal of Medicine·Giuseppe LippiGiovanni Targher
Jul 1, 2010·Diabetes Care·Xuanping ZhangAnn L Albright
Jul 14, 2010·Diabetes Care·Parinya ChamnanSimon J Griffin
Dec 28, 2010·Diabetes Research and Clinical Practice·Lawrence S C LawKaren S L Lam
Feb 19, 2011·Diabetes Care·Andrew O OdegaardMark A Pereira
Jul 28, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·A RamachandranA Nanditha
Jan 13, 2012·The Journal of Clinical Endocrinology and Metabolism·William H Herman, Robert M Cohen
Jan 31, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·K VenkataramanE Y H Khoo
Apr 19, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·Y HeianzaH Sone
Dec 3, 2013·Diabetes Research and Clinical Practice·UNKNOWN International Diabetes Federation
Sep 6, 2014·Diabetes Care·Ruth C E HughesJanet Rowan
Oct 24, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·O SevketS Kelekci
Citations
Feb 7, 2017·Scientific Reports·Jing WangMeian He
Oct 30, 2018·The Cochrane Database of Systematic Reviews·Bernd RichterYemisi Takwoingi
Jul 18, 2019·Obesity Surgery·Dror DickerRachel Golan
Apr 4, 2021·Biosensors·Miroslav Pohanka