Glycation endproducts, soluble receptor for advanced glycation endproducts and cytokines in diabetic and non-diabetic pregnancies

American Journal of Reproductive Immunology : AJRI
Magdalena Pertyńska-MarczewskaJan Wilczyński

Abstract

Cytokines, advanced glycation end products (AGEs), and their receptor RAGE have been recently suggested to play a role in human pregnancy. In this study, we sought to determine the alterations of plasma AGEs, soluble RAGE (sRAGE), and proinflammatory cytokines in normal pregnancies and those complicated with type 1 diabetes mellitus. These parameters were measured in samples from healthy non-pregnant (C), diabetic non-pregnant (D), healthy pregnant (HP), and pregnant diabetic (DP) women. In the first trimester, DP showed lower sRAGE and higher AGEs compared to HP. In the DP group, significant negative correlations were seen between TNF-alpha and lipopolysaccharide (LPS)-stimulated IotaL-6 in the first trimester and sRAGE in the third trimester. LPS-stimulated IL-12 was positively correlated with levels of AGEs in the third trimester. We detected several differences in the levels of AGEs, sRAGE, and proinflammatory cytokines between euglycemic and diabetic pregnancies.

References

Feb 29, 2000·American Journal of Obstetrics and Gynecology·J F Clapp, W Kiess
Oct 29, 2002·Seminars in Neonatology : SN·Roberto RomeroKarim Kalache
Aug 12, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Christy-Lynn M CookeSandra T Davidge
Sep 13, 2003·Journal of Neurochemistry·Sladjana Dukic-StefanovicGerald Münch
May 14, 2005·American Journal of Obstetrics and Gynecology·Robert L GoldenbergPatrick S Ramsey
Feb 20, 2007·American Journal of Obstetrics and Gynecology·Irina A BuhimschiCatalin S Buhimschi
Apr 10, 2007·Seminars in Nephrology·Adeline L Y TanMark E Cooper
Jan 29, 2008·Current Drug Targets·Norman E Cameron, Mary A Cotter

❮ Previous
Next ❯

Citations

Jun 17, 2011·Antioxidants & Redox Signaling·Martha LappasAlicia Jawerbaum
Feb 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Emily A OliverIrina A Buhimschi
Jul 20, 2011·Journal of Perinatal Medicine·Jae-Hyun KwonYong-Won Park
Dec 4, 2012·Fertility and Sterility·Georgios BoutziosEvanthia Diamanti-Kandarakis
Aug 21, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·Y YuT J Lyons
Jun 26, 2013·Free Radical Research·L Guedes-MartinsH Almeida
Sep 26, 2013·PloS One·Sudeshna GhoshSwagata Dasgupta
Dec 7, 2013·Chemico-biological Interactions·Subramanian UmadeviVellaichamy Elangovan
Feb 23, 2017·Archives of Endocrinology and Metabolism·João Paulo LoboDayane Alberton
Mar 22, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shuang Li, Huixia Yang
Apr 28, 2010·Nature Reviews. Nephrology·Vivette D'Agati, Ann Marie Schmidt
Feb 27, 2017·Sleep & Breathing = Schlaf & Atmung·Nazia KhanGhada Bourjeily
Aug 13, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Sophie M CoffengMaria G van Pampus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.