Glycation of glucose sensitive lysine residues K36, K438 and K549 of albumin is associated with prediabetes

Journal of Proteomics
Rajeshwari RathoreMahesh J Kulkarni

Abstract

Prediabetes is a risk factor for the development of diabetes. Early diagnosis of prediabetes may prevent the onset and progression of diabetes and its associated complications. Therefore, this study aimed at the identification of novel markers for efficient prediction of prediabetes. In this pursuit, we have evaluated the ability of glycated peptides of albumin in predicting prediabetes. Glycated peptides of in vitro glycated albumin were characterized by data dependent acquisition and parallel reaction monitoring using LC-HRMS. Amongst 14 glycated peptides characterized in vitro, four peptides, particularly, FK(CML)DLGEENFK, K(AML)VPQVSTPTLVEVSR, K(CML)VPQVSTPTLVEVSR, and K(AML)QTALVELVK, corresponding to 3 glucose sensitive lysine residues K36, K438, and K549, respectively showed significantly higher abundance in prediabetes than control. Additionally, the abundance of three of these peptides, namely K(AML)QTALVELVK, K(CML)VPQVSTPTLVEVSR and FK(CML)DLGEENFK was >1.8-fold in prediabetes, which was significantly higher than the differences observed for FBG, PPG, and HbA1c. Further, the four glycated peptides showed a significant correlation with FBG, PPG, HbA1c, triglycerides, VLDL, and HDL. This study supports that glycated pe...Continue Reading

References

Jul 16, 1992·Nature·X M He, D C Carter
Feb 1, 1990·Journal of Internal Medicine·P Gram-HansenL Olesen
Jun 1, 1980·Diabetes·R Dolhofer, O H Wieland
Aug 10, 2000·Diabetes/metabolism Research and Reviews·M I Harris, R C Eastman
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
Mar 30, 2004·Journal of the American Society for Mass Spectrometry·Annunziata LapollaRoberto Tonani
Sep 4, 2004·Acta Haematologica·Erkan CobanAysen Timuragaoglu
Aug 21, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chunling WaDavid S Hage
Jan 29, 2008·Current Pharmaceutical Design·G MisciagnaM Trevisan
Apr 10, 2008·Journal of Proteome Research·Qibin ZhangThomas O Metz
Feb 4, 2010·Molecular Diagnosis & Therapy·Takuji Kohzuma, Masafumi Koga
May 25, 2010·Analytical and Bioanalytical Chemistry·Andrej Frolov, Ralf Hoffmann
Nov 3, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Omar S BarnabyDavid S Hage
May 15, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cai-Mei ZhengKuo-Cheng Lu
Jul 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Fei Song, Ann Marie Schmidt
Aug 7, 2012·Molecular & Cellular Proteomics : MCP·Amelia C PetersonJoshua J Coon
Feb 22, 2014·The American Journal of the Medical Sciences·Aidar R Gosmanov, Jim Wan
Feb 26, 2014·Proteome Science·Mohammad R Nezami RanjbarHabtom W Ressom
Jul 25, 2014·Journal of Proteome Research·Ashley Beasley-GreenKaren W Phinney
Oct 16, 2014·Proteomics·Kedar B BatkulwarMahesh J Kulkarni
Feb 13, 2015·Nature Protocols·Olga T SchubertRuedi Aebersold
Jan 15, 2016·PloS One·Wan-Chen WuHung-Yuan Li
Feb 24, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Cato BredeØyvind Skadberg
Apr 9, 2016·Molecular & Cellular Proteomics : MCP·Shweta BhatMahesh J Kulkarni
Sep 15, 2016·Endocrine·Elena DozioMassimiliano Marco Corsi Romanelli
Jul 12, 2017·Expert Review of Proteomics·Shweta BhatMahesh J Kulkarni
Sep 2, 2017·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Brenda DorcelyMichael Bergman
Jun 28, 2018·Hormones : International Journal of Endocrinology and Metabolism·Michael ApostolakisEleni Anastasiou
Nov 10, 2018·ACS Omega·Mashanipalya G JagadeeshaprasadMahesh J Kulkarni
Nov 14, 2018·Mass Spectrometry Reviews·Sara D'AroncoAnnunziata Lapolla

❮ Previous
Next ❯

Citations

Jun 25, 2020·Expert Review of Proteomics·Khushman TaunkSrikanth Rapole
Nov 18, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mustapha Zendjabil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.