PMID: 8595250Oct 1, 1995Paper

Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients

Glycoconjugate Journal
A S Duhaiman

Abstract

Glycation (nonenzymatic glycosylation) in the human lens (cortex and nucleus) in senile (nondiabetic) and diabetic cataracts was studied by measuring the extent of early and late glycation products, the content of free epsilon-amino groups and the formation of disulfide bonds in the soluble lens proteins. There was a significant (p < 0.001) increase in early and late glycation in the lens nucleus compared to the cortex in both the senile and diabetic groups. Overall these changes were much larger in the diabetic group. The concentration of free epsilon-amino groups was decreased in the senile nucleus as well as in the diabetic nucleus when compared with the senile and diabetic cortex (p < 0.001). Disulfide bond content was in the order of diabetic nucleus > diabetic cortex > senile nucleus > senile cortex. Glycation of the lens proteins is a generalized feature which is enhanced in the diabetic lens compared to senile lens proteins and is associated with a decrease in free epsilon-amino groups and an increase in disulfide bonds formation in the lens proteins.

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Citations

Jan 1, 2004·Indian Journal of Clinical Biochemistry : IJCB· Jansirani, P H Anathanaryanan
Apr 9, 2002·Clinical Biochemistry·Bilgin OzmenOya Bayindir
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·N Trostler
Jul 29, 1998·Free Radical Biology & Medicine·I GrattaglianoE Altomare
Jun 13, 2012·Biological & Pharmaceutical Bulletin·Ken KawakuboKunio Ishii
Apr 23, 2009·Indian Journal of Ophthalmology·S K GuptaRohit Saxena
Oct 3, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Jadwiga PietkiewiczRegina Danielewicz
May 4, 2004·Journal of Diabetes and Its Complications·Z KyselovaV Bauer
Mar 14, 2000·Experimental Eye Research·F A ShamsiR H Nagaraj
Apr 24, 2008·Journal of Pharmacological Sciences·Sokichi KametakaKunio Ishii
Oct 3, 2018·Biological & Pharmaceutical Bulletin·Yoshihiro HigashiTsutomu Nakahara
Mar 13, 2019·International Journal of Environmental Research and Public Health·Declan Timothy Waugh

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