Glycemia and prognosis of patients with chronic heart failure--subanalysis of the Long-term Prospective Randomized Controlled Study Using Repetitive Education at Six-Month Intervals and Monitoring for Adherence in Heart Failure Outpatients (REMADHE) trial

American Heart Journal
Victor Sarli IssaEdimar Alcides Bocchi

Abstract

Heart failure and diabetes often occur simultaneously in patients, but the prognostic value of glycemia in chronic heart failure is debatable. We evaluated the role of glycemia on prognosis of heart failure. Outpatients with chronic heart failure from the Long-term Prospective Randomized Controlled Study Using Repetitive Education at Six-Month Intervals and Monitoring for Adherence in Heart Failure Outpatients (REMADHE) trial were grouped according to the presence of diabetes and level of glycemia. All-cause mortality/heart transplantation and unplanned hospital admission were evaluated. Four hundred fifty-six patients were included (135 [29.5%] female, 124 [27.2%] with diabetes mellitus, age of 50.2 +/- 11.4 years, and left-ventricle ejection fraction of 34.7% +/- 10.5%). During follow-up (3.6 +/- 2.2 years), 27 (5.9%) patients were submitted to heart transplantation and 202 (44.2%) died; survival was similar in patients with and without diabetes mellitus. When patients with and without diabetes were categorized according to glucose range (glycemia < or = 100 mg/dL [5.5 mmol/L]), as well as when distributed in quintiles of glucose, the survival was significantly worse among patients with lower levels of glycemia. This finding ...Continue Reading

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May 11, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Aslan T TurerMihai V Podgoreanu
Dec 19, 2013·BioMed Research International·Fernando A BotoniManoel Otávio C Rocha
Nov 17, 2012·Journal of Cardiothoracic Surgery·Carlos José Soares de AraújoVitor Oliveira Carvalho
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Mar 13, 2014·Archives of Cardiovascular Diseases·Maria Grazia AlbanoJean-François d'Ivernois
Jan 9, 2019·The Cochrane Database of Systematic Reviews·Andrea TakedaStephanie Jc Taylor

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