PMID: 3769715Sep 1, 1986Paper

Glycemic control and bone age are independently associated with muscle capillary basement membrane width in diabetic children after puberty

Diabetes Care
D G RogersJ R Williamson

Abstract

This study was undertaken to examine the possible relationships between muscle capillary basement membrane width (CBMW) and glycemic control, bone age, chronologic age, and duration of diabetes in young patients with insulin-dependent diabetes mellitus (IDDM) during different stages of pubertal development. We studied 49 males and 43 females (age, 7-20 yr) with IDDM for up to 16 yr for whom bone age and glycosylated hemoglobin (HbA1c) data were available at the time of right quadriceps muscle biopsy. Based on pubic hair Tanner stage, subjects were assigned to prepubertal (Tanner I), pubertal (Tanner II and III), and postpubertal (Tanner IV and V) groups. In 30 pubertal and prepubertal subjects, none of the variables studied was significantly correlated with CBMW. This is attributable in part to the small number of subjects in each group. In 62 postpubertal subjects, CBMW was correlated with age (r = .27, P = .03), bone age (r = .43, P = .0005), and postpubertal duration of diabetes (r = .38, P = .003) but not total duration of diabetes. In the postpubertal subjects, CBMW was correlated with HbA1c at the time of biopsy (r = .31, P = .01) but correlated more strongly with the mean of HbA1c values obtained during the 1- and 2-yr p...Continue Reading

Citations

Aug 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·A C ShoreJ E Tooke
Jan 1, 1994·Archives of Disease in Childhood·A C ShoreJ E Tooke
Jan 1, 1987·Diabetes Research and Clinical Practice·D G RogersJ V Santiago
Oct 8, 2016·Clinical Hemorheology and Microcirculation·Z StoynevaI Koleva
Jan 6, 2015·Developmental Biology·Alice P ChristensenSuzannah A Williams
Mar 1, 1992·Clinical Pediatrics·D G Rogers

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