Glycemic Control with Thiazolidinedione Is Associated with Fracture of T2DM Patients

PloS One
Hsin-Hung ChenChia-Hung Kao

Abstract

Diabetes is a common diseases and a major problem worldwide. Diabetic osteopathy might be elevated in diabetic patients and is usually caused by bone fracture. Several diabetes medications, such as thiazolidinediones (TZDs), could lead to increased risks of fracture. We used the nationwide database to identified 32466 patients who had developed type 2 diabetes from 2000 to 2010 as the diabetic cohort and, from that group, we selected 3427 diabetic patients who had developed bone fracture to survey the possible risk factors, includng commonly used diabetes medication. We found that TZDs might present increased risks for fracture in patients who used it for an extended period (7 to 730 days before the index date), especially in female patients younger than 64 years old, for whom the risk was elevated from a 1.74- to a 2.58-fold odds ratio. We recommend that clinics follow up with non-osteoporotic female patients younger than 64 years old who are using TZDs, to avoid the associated risks of fracture.

References

Sep 1, 1991·Calcified Tissue International·R Bouillon
Jul 1, 1988·Clinical Orthopaedics and Related Research·R T Loder
Sep 28, 1999·Diabetes Research and Clinical Practice·P DamsboP G Müller
Jul 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·S MadsbadUNKNOWN Scandinavian Repaglinide Group
Sep 10, 2004·The New England Journal of Medicine·Hannele Yki-Järvinen
Dec 6, 2006·The New England Journal of Medicine·Steven E KahnUNKNOWN ADOPT Study Group
Jun 19, 2007·American Journal of Epidemiology·Mohsen JanghorbaniFrank B Hu
Jun 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Zehra BerberogluNilgun Guvener Demirag
Jun 10, 2008·The New England Journal of Medicine·UNKNOWN Action to Control Cardiovascular Risk in Diabetes Study GroupWilliam T Friedewald
Dec 17, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Yoon K LokeCurt D Furberg
Sep 26, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Natasha B KhazaiGuillermo E Umpierrez
Jul 16, 2010·Age and Ageing·Deborah MayneTerry J Aspray
Sep 3, 2010·Current Osteoporosis Reports·Beata Lecka-Czernik
Dec 8, 2011·Expert Opinion on Drug Safety·Christopher M SimpsonPeter V Giannoudis
Feb 15, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M C LinC H Kao
Apr 4, 2013·Frontiers in Endocrinology·Marloes T BazelierTjeerd-Pieter van Staa

❮ Previous
Next ❯

Citations

Apr 26, 2017·Endocrinología, Diabetes Y Nutrición·Pedro Rozas-MorenoUNKNOWN en representación del Grupo de Trabajo de Osteoporosis y Metabolismo Mineral de la Sociedad Española de Endocrinología y Nut
Mar 28, 2017·Therapeutic Advances in Musculoskeletal Disease·Vikram SundararaghavanNabil A Ebraheim
Mar 24, 2018·Clinical and Experimental Pharmacology & Physiology·Artur StolarczykAgnieszka Cudnoch-Jędrzejewska
Nov 24, 2018·Diabetes/metabolism Research and Reviews·Evangelia KalaitzoglouKathryn M Thrailkill
May 14, 2019·Expert Opinion on Biological Therapy·Sahar MohsinErnest A Adeghate
Nov 14, 2017·Pharmacological Reports : PR·Mohammad AdilManju Sharma
Aug 12, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B-B QianC-F Yan
Aug 9, 2019·Current Osteoporosis Reports·Lamya KarimRachana Vaidya
Sep 21, 2019·Journal of Cellular Physiology·Naiomy D Rios-ArceNarayanan Parameswaran
Jun 23, 2020·Journal of Diabetes Research·C Eller-VainicherL Gennari
Sep 17, 2019·World Journal of Diabetes·Silvia Costantini, Caterina Conte
Nov 10, 2020·Current Osteoporosis Reports·Z Al-MashhadiJakob Starup-Linde
Jun 30, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Kendall F MoseleyEve Donnelly

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

PROactive
SAS

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Related Papers

Current Osteoporosis Reports
Andrew Grey
Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Abhijeet Goyal, Errol D Crook
© 2021 Meta ULC. All rights reserved