Glycemic impact of non-nutritive sweeteners: a systematic review and meta-analysis of randomized controlled trials

European Journal of Clinical Nutrition
Alexander D NicholRuopeng An

Abstract

Nonnutritive sweeteners (NNSs) are zero- or low-calorie alternatives to nutritive sweeteners, such as table sugars. A systematic review and meta-analysis of randomized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs. PubMed and Web of Science databases were searched. Two authors screened the titles and abstracts of candidate publications. The third author was consulted to resolve discrepancies. Twenty-nine randomized controlled trials, with a total of 741 participants, were included and their quality assessed. NNSs under examination included aspartame, saccharin, steviosides, and sucralose. The review followed the PRISMA guidelines. Meta-analysis was performed to estimate and track the trajectory of blood glucose concentrations over time after NNS consumption, and to test differential effects by type of NNS and participants' age, weight, and disease status. In comparison with the baseline, NNS consumption was not found to increase blood glucose level, and its concentration gradually declined over the course of observation following NNS consumption. The glycemic impact of NNS consumption did not differ by type of NNS but to some extent varied by participant...Continue Reading

References

Sep 1, 1992·Behavioral and Neural Biology·C A ManningP E Gold
Mar 1, 1988·Diabetes Care·D L HorwitzP Kobe
Jan 1, 1987·Physiology & Behavior·L Gonder-FrederickP E Gold
Oct 1, 1985·Journal of Nutritional Science and Vitaminology·H ShigetaM Kondo
Jun 1, 1973·Food and Cosmetics Toxicology·E W McChesney, L Golberg
May 1, 1997·Neurobiology of Aging·C MessierV Knott
Jan 22, 1998·The Journal of Clinical Endocrinology and Metabolism·U N NguyenJ Regnard
Jul 11, 1998·Behavioural Brain Research·C A ManningP E Gold
Jul 31, 1998·Psychopharmacology·J K FosterS I Sünram
Jul 23, 1999·Schizophrenia Bulletin·J W NewcomerR Miller
Aug 15, 2001·The British Journal of Nutrition·M W GreenO Rhodes
May 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eriko KoyamaMichio Ui
Jun 12, 2003·Behavioural Brain Research·Robert W Flint, Crystal Turek
Aug 4, 2004·Psychopharmacology·Ivan BerlinOdile Spreux-Varoquaux
Dec 23, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Ludovico CoppolaGiorgio Gombos
Nov 11, 2005·The American Journal of Clinical Nutrition·Paul A M SmeetsJeroen van der Grond
May 23, 2006·Biological Psychology·Karen R BrandtKirsty Qualtrough
Sep 26, 2009·Eating Behaviors·Elizabeth A DennisBrenda M Davy
Oct 10, 2009·Physiology & Behavior·D P FiglewiczC L Roth
Jan 12, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A G TsaiH A Glick
Mar 9, 2010·Bioscience, Biotechnology, and Biochemistry·Yuji MurataYoshihisa Nakano
Apr 29, 2010·Psychological Science·X T Wang, Robert D Dvorak
Jan 25, 2011·The British Journal of Nutrition·Robert E SteinertChristoph Beglinger
Aug 9, 2011·European Journal of Epidemiology·Susanne MoebusKarl-Heinz Jöckel
Dec 14, 2011·The American Journal of Clinical Nutrition·Tongzhi WuChristopher K Rayner
Mar 14, 2012·Diabetes Care·Rebecca J BrownKristina I Rother
Jun 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Rebecca J Brown, Kristina I Rother
Jul 11, 2012·Circulation·Christopher GardnerUNKNOWN American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity and Metabolism, Council on Art
Oct 6, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Anne Raben, Bjørn Richelsen
Feb 14, 2013·Appetite·Shirin PanahiG Harvey Anderson
Mar 15, 2013·BMJ : British Medical Journal·Lisa Te MorengaSimonette Mallard
Apr 4, 2013·Cardiovascular Diabetology·Matilde E Otero-LosadaJosé Milei
May 25, 2013·Endocrinology and Metabolism Clinics of North America·Rita Rastogi Kalyani, Josephine M Egan
Jul 13, 2013·Nutrition·Padmini ShankarKrishnan Sriram
Jul 16, 2013·Trends in Endocrinology and Metabolism : TEM·Susan E Swithers
Nov 1, 2013·Psychological Science·Lene Aarøe, Michael Bang Petersen

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Citations

Apr 20, 2019·Diabetes Care·Alison B EvertWilliam S Yancy
Apr 27, 2019·The Proceedings of the Nutrition Society·Alison M Gallagher, Caomhán Logue
Apr 30, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Samar Y AhmadDylan MacKay
Jan 14, 2020·Nutrition Research Reviews·Margaret AshwellCarlo la Vecchia
May 27, 2020·Médecine sciences : M/S·Alexandra Pepin, Pascal Imbeault
Mar 21, 2019·International Journal of Food Sciences and Nutrition·Luke SolomiKathy M Redfern
Dec 1, 2018·European Journal of Clinical Nutrition·Sydney RisdonGuillaume Walther
Nov 20, 2019·Current Atherosclerosis Reports·Yoona KimPeter M Clifton
Mar 28, 2020·Critical Reviews in Food Science and Nutrition·Amar D E Van LaarJohn Van Camp
Jan 12, 2020·Advances in Nutrition·David J MelaPeter J Rogers
Apr 17, 2020·Journal of the Science of Food and Agriculture·Khaing Zar MyintJue Zhang
Nov 26, 2020·Nutrition Reviews·Lesley AndradeSharon I Kirkpatrick
Jan 12, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Hugo Laviada-MolinaFernanda Molina-Segui
Mar 2, 2021·International Journal of Food Sciences and Nutrition·Samuel Mendoza-PérezMaría-Del-Carmen Durán-Domínguez-de-Bazúa
Oct 30, 2019·Pediatrics·Carissa M Baker-SmithUNKNOWN COMMITTEE ON NUTRITION, SECTION ON GASTROENTEROLOGY, HEPATOLOGY, AND NUTRITION
Feb 9, 2021·Clinical Diabetes : a Publication of the American Diabetes Association·Hope Warshaw, Steven V Edelman

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