Glycemic Measures and Development and Resolution of Nonalcoholic Fatty Liver Disease in Nondiabetic Individuals.

The Journal of Clinical Endocrinology and Metabolism
Bin WangYu Xu

Abstract

Type 2 diabetes (T2D) is closely associated with nonalcoholic fatty liver disease (NAFLD); however, evidence regarding the link between blood glucose, especially below the threshold for T2D, and NAFLD is scarce. The objective of this work is to examine the associations of fasting glucose, oral glucose tolerance test (OGTT) 2-hour glucose, and hemoglobin A1c (HbA1c), and changes in these measures with development and resolution of NAFLD in nondiabetic individuals. This longitudinal cohort study comprised 4273 Chinese adults age 40 years or older and free of baseline T2D from 2010 to 2015. Blood sampling was performed during the OGTT test. NAFLD was ascertained by hepatic ultrasonography. Risk ratios (RRs) were calculated using modified Poisson regression models. During a mean 4.4 years of follow-up, NAFLD occurred in 573 (17.9%) of the 3209 participants without baseline NAFLD and resolved in 304 (28.6%) of the 1064 participants with baseline NAFLD. OGTT 2-h glucose was positively associated with NAFLD incidence (RR per 1-SD increase: 1.16, 95% CI: 1.08-1.25), whereas fasting (RR: 0.86, 95% CI: 0.78-0.94) and 2-hour glucose (RR: 0.85, 95% CI: 0.77-0.93) were inversely associated with resolution of NAFLD. Glycemic deterioration co...Continue Reading

References

May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Mar 30, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Leon A AdamsKeith D Lindor
Oct 22, 2008·Trends in Endocrinology and Metabolism : TEM·Herbert Tilg, Alexander R Moschen
Nov 19, 2008·Journal of Hepatology·Jian-Gao Fan, Geoffrey C Farrell
Oct 23, 2009·Journal of Hepatology·Srinivasan DasarathyArthur J McCullough
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Jul 16, 2010·The American Journal of Gastroenterology·Ji Cheol BaeByung Ik Kim
Dec 16, 2010·Journal of Gastroenterology and Hepatology·Jayani ManchanayakeGeoffrey C Farrell
May 11, 2011·Nature Reviews. Endocrinology·Briohny W Smith, Leon A Adams
Dec 15, 2012·Endocrine Reviews·K H WilliamsS M Twigg
Mar 6, 2013·Nature Reviews. Gastroenterology & Hepatology·Geoffrey C FarrellShiv Chitturi
Jun 12, 2013·Journal of Hepatology·Fabio NascimbeniAmedeo Lonardo
Sep 18, 2013·Nature Reviews. Gastroenterology & Hepatology·Rohit Loomba, Arun J Sanyal
Dec 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiMark Wymer
Jun 9, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Luca ValentiGiovanni Targher
Oct 21, 2016·European Journal of Gastroenterology & Hepatology·Takuya FukudaMichiaki Fukui
Jun 24, 2017·Journal of Hepatology·Jian-Gao FanVincent Wai-Sun Wong
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Limin WangLinhong Wang
May 8, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yuanjie PangZhengming Chen
May 10, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Feng ZhouHongliang Li

❮ Previous
Next ❯

Citations

Jan 1, 2021·The American Journal of Clinical Nutrition·Nynke SimonsMartijn C G J Brouwers
Mar 17, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anastasia-Stefania AlexopoulosManal F Abdelmalek
Jun 20, 2021·Diabetes Research and Clinical Practice·So-Hyeon HongKyung Mook Choi
Jun 15, 2021·The Journal of Clinical Endocrinology and Metabolism·Guangmin ZuoMin Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.