Glycemic patterns detected by continuous subcutaneous glucose sensing in children and adolescents with type 1 diabetes mellitus treated by multiple daily injections vs continuous subcutaneous insulin infusion

Archives of Pediatrics & Adolescent Medicine
Naomi WeintrobMoshe Phillip

Abstract

To compare glycemic patterns by mode of therapy in children with type 1 diabetes mellitus using the Continuous Glucose Monitoring System (CGMS). Open randomized crossover comparing 3(1/2) months of multiple daily injections (MDI) and continuous subcutaneous insulin infusion (CSII). Tertiary care, university-affiliated medical center. Patients Twenty-three children and adolescents with type 1 diabetes mellitus. The CGMS was applied for 72 hours after 1 month and at the end of each study arm. Hemoglobin A(1c) levels and glucose level profiles were compared between the 2 study arms and the 2 sensor applications for each arm. The arms were similar for mean (SD) hemoglobin A(1c) levels (CSII, 8.0% [0.8%]; and MDI, 8.2% [0.8%]) and glucose levels. Areas under the curve were significantly larger during MDI for nocturnal and 24-hour hypoglycemia (P =.01 and.04, respectively) and for postprandial hypoglycemia and hyperglycemia (P =.03 and.05, respectively). The rate of hyperglycemia increased during CSII (P =.03), but 24-hour duration and area under the curve for hyperglycemia were similar. Compared with the first CGMS reading in each arm, the second had a longer mean duration of postprandial within-target glucose levels (P =.04), tende...Continue Reading

Citations

Nov 30, 2010·Journal of the American Dietetic Association·Marion J FranzErica Gradwell
May 20, 2011·European Journal of Pediatrics·Senthil SenniappanUNKNOWN North West England Paediatric Diabetes Network
Apr 15, 2008·Endocrinology and Metabolism Clinics of North America·Samuel L EllisKenneth E Izuora
Nov 23, 2005·Pediatric Clinics of North America·Christopher RyanDorothy Becker
Jan 28, 2009·Diabetes/metabolism Research and Reviews·Daniela BruttomessoAldo Baritussio
Mar 26, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·C E SmartB R King
Jan 31, 2012·Pediatric Diabetes·Moshe PhillipUNKNOWN Consensus Forum Participants
Nov 17, 2011·Journal of Paediatrics and Child Health·Martin de BockCraig Jefferies
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·S ShalitinM Phillip
Jul 14, 2012·Advances in Pediatrics·Shideh Majidi, David M Maahs
Jun 1, 2008·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Emilio García-GarcíaAntonio Bonillo
Aug 16, 2014·Journal of Diabetes Science and Technology·Ana Maria Gomez, Guillermo E Umpierrez
Jul 5, 2011·Journal of Diabetes Science and Technology·Douglas MuchmoreDaniel Vaughn
Jan 1, 2008·Journal of Diabetes Science and Technology·Alice ChanBoris P Kovatchev
Jul 1, 2008·Journal of Diabetes Science and Technology·Christophe De BlockLuc Van Gaal
May 31, 2014·Journal of Diabetes Science and Technology·Erik A Otto, Vinay Tannan
Oct 16, 2012·Journal of Diabetes Science and Technology·Baraka FloydGuillermo E Umpierrez
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Marie L MissoJonathan Shaw
Oct 20, 2005·Journal of Neuroscience Research·Amy B CriegoElizabeth R Seaquist
Mar 15, 2006·Medicine and Science in Sports and Exercise·Adam L MacDonaldPeter W Watt
Jan 1, 2010·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Tatsuhiko UrakamiHideo Mugishima
Sep 26, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·David D MartinTimothy W Jones

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