PMID: 7035630Jan 1, 1982Paper

Glycemic response to lipid infusion in the premature neonate

The Journal of Pediatrics
R A VileisisW Oh

Abstract

The effect of lipid infusion on glucose homeostasis in the preterm newborn infant was evaluated. Seven infants were given a test dose of 0.25 gm/kg/hour of lipid emulsion. Their response was characterized by :(1) a two fold increase in serum free fatty acid concentrations, (2) a small, transient rise in insulin values, and (3) a sustained increase in serum glucose concentration (mean increment in serum glucose was 24% over baseline). Nine infants received a test dose of 0.5 gm/kg/hr of lipid. Their response was similar to that in the lower infusion group, but of a greater magnitude: an eightfold increase in free fatty acids, sustained increase in serum insulin concentration, and a mean increment in serum glucose values of 65% over baseline. Increased lipid availability in the low-birth-weight newborn infant plays a significant role in promoting an increase in serum glucose concentrations.

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Citations

Jul 1, 1993·Baillière's Clinical Endocrinology and Metabolism·M P Platt, J M Hawdon
Mar 1, 1983·Archives of Disease in Childhood·M F WhitfieldR D Milner
Jan 1, 1994·Archives of Disease in Childhood. Fetal and Neonatal Edition·A Mehta
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Feb 24, 2015·Clinical Medicine Insights. Pediatrics·Ghassan Sa SalamaMohammad Ia Alquran
Nov 18, 2005·American Journal of Physiology. Endocrinology and Metabolism·Anne A M W van KempenHans P Sauerwein
Mar 4, 2003·Pediatric Research·Agneta L Sunehag
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Nov 1, 1992·The American Journal of Physiology·K A YunisR M Cowett

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