PMID: 8955462Nov 1, 1996Paper

Glycerol carbon contributes to hepatic glucose production during the first eight hours in healthy term infants

Acta Paediatrica
A SunehagU Ewald

Abstract

The newborn infant must mobilize endogenous substrate stores to meet the requirements of glucose-dependent organs. High concentrations of free fatty acids and glycerol, and a rapid decrease in the respiratory quotient, indicate that lipids are an important fuel soon after birth. The purpose of the present study was to determine the onset of lipolysis and gluconeogenesis from glycerol in healthy, term, unfed infants. Eight infants were studied from a postnatal age of 3.5 +/- 0.5 h to 7.4 +/- 0.2 h using [6,6-2H2] glucose and [2-13C]glycerol analysed by gas chromatography/mass spectrometry. Plasma concentrations of glucose, glycerol and insulin averaged 2.9 +/- 0.4 mM, 369 +/- 89 microM and 9.4 +/- 9.4 +/- 3.7 microU.ml-1, respectively. The hepatic glucose production rate averaged 25.0 +/- 3.5 mumol.kg-1 min-1 (4.5 +/- 0.6 mg.kg-1.min-1) and the endogenous plasma appearance rate of glycerol 8.7 +/- 1.2 mumol.kg-1.min. On average, 57.9 +/- 8.4% of the glycerol was converted to glucose, representing 11.1 +/- 2.3% of hepatic glucose output. Thus, lipolysis and gluconeogenesis from glycerol are established within the first 8 h of life in term infants.

References

Apr 1, 1992·Archives of Disease in Childhood·J M HawdonA Aynsley-Green
Jan 1, 1990·Biology of the Neonate·J Girard
Nov 1, 1988·The Journal of Clinical Investigation·C MarcusP Arner
Feb 1, 1986·Pediatric Clinics of North America·E S Ogata
Jan 1, 1986·Biology of the Neonate·J Girard
Nov 1, 1970·Acta paediatrica Scandinavica·J Senterre, P Karlberg
Jan 1, 1993·Biology of the Neonate·P L MehandruS C Kalhan
May 1, 1957·Acta Paediatrica·K W CROSSD A TRYTHALL

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Citations

May 27, 2005·Seminars in Fetal & Neonatal Medicine·Martin Ward Platt, Sanjeev Deshpande
Mar 29, 2001·Thyroid : Official Journal of the American Thyroid Association·T AsamiM Uchiyama
Apr 9, 2008·Annual Review of Nutrition·Satish C Kalhan, Dennis M Bier
Aug 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Mahmoud A MohammadMorey W Haymond
Mar 4, 2003·Pediatric Research·Agneta L Sunehag
Dec 26, 2006·Acta Paediatrica·Barbro DiderholmJan Gustafsson
Jan 26, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Maciej JóźwikFrederick C Battaglia
May 11, 2000·Seminars in Perinatology·S Kalhan, P Parimi
Aug 10, 2002·Clinics in Perinatology·Agneta L Sunehag, Morey W Haymond
Jun 9, 2009·Metabolism: Clinical and Experimental·Wilco C W R ZijlmansHans P Sauerwein
Dec 28, 1999·Endocrinology and Metabolism Clinics of North America·M W Haymond, A Sunehag
Jun 11, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maria Halldin StenlidJan Gustafsson
Jan 12, 2008·Journal of Applied Physiology·Shaji K ChackoMorey W Haymond
Aug 6, 2013·Journal of Diabetes Science and Technology·Jennifer L DicksonJ Geoffrey Chase
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·S C KalhanP J Sauer
Nov 3, 2007·Pediatrics·Fredrik S E AhlssonJan Gustafsson

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