Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases.

Journal of Bacteriology
R G Forage, M A Foster

Abstract

Glycerol and diol dehydratases are inducible, coenzyme B12-dependent enzymes found together in Klebsiella pneumoniae ATCC 25955 during anaerobic growth on glycerol. Mutants of this strain isolated by a novel procedure were separately constitutive for either dehydratase, showing the structural genes for the two enzymes to be under independent control in vivo. Glycerol dehydratase and a trimethylene glycol dehydrogenase were implicated as members of a pleiotropic control system that includes glycerol dehydrogenase and dihydroxyacetone kinase for the anaerobic dissimilation of glycerol (the "dha system"). The dehydratase and dehydrogenases were induced by dihydroxyacetone and were jointly constitutive in mutants isolated as constitutive for either the dha system or glycerol dehydratase. These data and the stimulation of growth by Co2+ suggested that glycerol dehydratase and trimethylene glycol dehydrogenase are obligatory enzymes for anaerobic growth on glycerol as the sole carbon source.

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Citations

Sep 17, 2002·European Journal of Biochemistry·Mamoru YamanishiTetsuo Toraya
Apr 28, 2009·Applied Microbiology and Biotechnology·Kaloyan Petrov, Penka Petrova
Oct 15, 2011·Critical Reviews in Biotechnology·E Celińska
Oct 28, 2016·Current Microbiology·Kang Wang, Pingfang Tian
Oct 9, 2002·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Tetsuo Toraya
Aug 26, 2014·Applied and Environmental Microbiology·Björn AndreessenAlexander Steinbüchel
Mar 16, 2013·Applied Microbiology and Biotechnology·Kris Niño G ValdehuesaSi Jae Park
Mar 12, 2016·Biotechnology for Biofuels·Wei JiangBaishan Fang
Aug 30, 2016·Indian Journal of Microbiology·Liuni ChenPingfang Tian
Mar 26, 2015·Indian Journal of Microbiology·Ying Li, Pingfang Tian
Jan 28, 1999·The Journal of Biological Chemistry·T Toraya, K Mori
Apr 10, 2010·Journal of Industrial Microbiology & Biotechnology·Yu-Tze HorngPo-Chi Soo
Mar 1, 2012·Journal of Bacteriology·Joanna L McKenzieGregory M Cook
Feb 19, 2014·Applied Microbiology and Biotechnology·Chuan ChenJian Hao
Jan 1, 1996·Annual Review of Microbiology·J R RothT A Bobik

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