Glycerol-induced injury as a new model of muscle regeneration

Cell and Tissue Research
Mohamed A A Mahdy

Abstract

Skeletal muscle regenerates efficiently following injuries and diseases. However, muscle regeneration is compromised in several conditions by adipocyte infiltration and excessive collagen deposition. Adipocyte infiltration is a characteristic feature of sarcopenia, diabetes, cachexia, muscular dystrophies and advanced cases of Duchenne muscular dystrophy (DMD), while excessive collagen deposition is a hallmark of muscular dystrophies and severe muscle injuries, such as lacerations, contusions and strains. Muscle adipogenesis and fibrosis are major causes of muscle weakness that impairs muscle function. Therefore, it is essential to develop an appropriate injury model to understand the mechanisms of adipocyte formation and fibrosis during muscle regeneration. This will help to advance our knowledge regarding the events that occur in dystrophic muscle diseases and develop innovative therapies for such pathological conditions. To date, several experimental injury models have been used to investigate skeletal muscle regeneration. Intramuscular injection of glycerol has been used as a new model to induce muscle injury and regeneration. It was reported that degenerative changes following glycerol-induced injury resemble those seen in...Continue Reading

References

Jan 1, 1990·Acta Neuropathologica·H KawaiM Iwasa
Jun 1, 1990·Neuropathology and Applied Neurobiology·C J CaldwellR O Weller
Sep 1, 1988·The Anatomical Record·E SchultzT L David
Jul 1, 1982·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·S Gomez, L S Queiroz
Aug 1, 1995·Journal of Muscle Research and Cell Motility·Y Bassaglia, J Gautron
Jul 1, 1993·The American Journal of Physiology·H TamaiT S Gaginella
Jan 1, 1996·Advances in Experimental Medicine and Biology·A T Tu
Feb 6, 1999·The American Journal of Sports Medicine·J M BeinerM M Panjabi
Jan 5, 2002·Differentiation; Research in Biological Diversity·A AsakuraM Rudnicki
Nov 28, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·F William Blaisdell
Dec 13, 2002·The Journal of Biological Chemistry·Zhen YanR Sanders Williams
Jan 31, 2003·The Journal of Biological Chemistry·Joshua R Sanes
May 13, 2003·Journal of Anatomy·J B HarrisM J Cullen
Jan 13, 2004·Physiological Reviews·Sophie B P Chargé, Michael A Rudnicki
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·J B Harris
Oct 7, 2004·Journal of Cell Science·Gabi SheferZipora Yablonka-Reuveni
Oct 29, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Nikola ArsicMauro Giacca
Jan 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James G Tidball
Sep 13, 2006·Acta histochemica·Harutoshi SakakimaYoshihiro Yoshida
Dec 22, 2006·Ultrastructural Pathology·Panorea K PolitiGeorge Lyritis
May 5, 2007·The Journal of Physiology·Gordon L WarrenPetia P Simeonova
May 9, 2007·The Journal of Experimental Medicine·Ludovic ArnoldBénédicte Chazaud
May 10, 2007·Molecular and Cellular Biochemistry·Akira Wagatsuma
Sep 9, 2008·Experimental Cell Research·Masashi SegawaHiroshi Yamamoto
Oct 22, 2008·Sports Medicine·Carine SmithKathryn H Myburgh
May 14, 2009·Journal of Muscle Research and Cell Motility·Simona ApostolWerner Melzer
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·Isabelle DesguerreChristo Christov
Aug 22, 2009·Blood·Oliver SoehnleinChristian Weber
Jan 19, 2010·Nature Cell Biology·Aaron W B JoeFabio M V Rossi
Mar 23, 2010·The American Journal of Pathology·So-ichiro FukadaHiroshi Yamamoto
May 12, 2010·Biochemical and Biophysical Research Communications·Didier F PisaniClaude A Dechesne
May 15, 2010·Journal of Biomedicine & Biotechnology·A VignaudA Ferry
Sep 2, 2010·International Journal of Experimental Pathology·Jussara Lagrota-CandidoThereza Quirico-Santos
Dec 15, 2010·Acta Orthopaedica·Tobias WinklerStephan V Tohtz
May 31, 2011·Current Topics in Developmental Biology·Antonio L SerranoPura Muñoz-Cánoves
Jul 30, 2011·Skeletal Muscle·Christopher J MannPura Muñoz-Cánoves
Sep 29, 2011·Muscle & Nerve·Allison R Gillies, Richard L Lieber
Nov 3, 2011·Journal of Cell Science·Akiyoshi UezumiSo-ichiro Fukada
Nov 15, 2011·The Journal of Nutritional Biochemistry·Kathryn H MyburghCarine Smith
Nov 25, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Yousuke MurakamiMasugi Nishihara

❮ Previous
Next ❯

Citations

Jan 4, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andrew DunnKoyal Garg
Dec 5, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carlin LeeBrian T Feeley
May 3, 2020·The Journal of Physiology·Nicole K BiltzGretchen A Meyer
Oct 5, 2018·The Journal of Veterinary Medical Science·Mohamed A A MahdyYoshinao Z Hosaka
Jul 14, 2020·Frontiers in Molecular Neuroscience·Matteo RigonRüdiger Rudolf
Nov 14, 2018·Cell and Tissue Research·Mohamed A A Mahdy
Sep 30, 2020·Journal of Cellular Physiology·Liyi Wang, Tizhong Shan
Jul 31, 2019·Journal of Muscle Research and Cell Motility·Mohamed A A Mahdy
Nov 28, 2020·Journal of Cachexia, Sarcopenia and Muscle·Ziye XuTizhong Shan

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Related Papers

Cell and Tissue Research
Mohamed A A Mahdy
The Journal of Veterinary Medical Science
Mohamed A A MahdyYoshinao Z Hosaka
Archives of Oral Biology
Alexander SpassovChristiane Kunert-Keil
© 2022 Meta ULC. All rights reserved