PMID: 9422612Jan 9, 1998Paper

Glycerol monolaurate inhibits induction of vancomycin resistance in Enterococcus faecalis

Journal of Bacteriology
A Ruzin, R P Novick

Abstract

Glycerol monolaurate (GML) is a surfactant that has been found to inhibit the post-exponential phase activation of virulence factor production and the induction of beta-lactamase in Staphylococcus aureus. It has been suggested that signal transduction is the most probable target for GML (S. J. Projan, S. Brown-Skrobot, P. M. Schlievert, F. Vandenesch, and R. P. Novick, J. Bacteriol. 176:4204-4209, 1994). We found that GML suppresses growth of vancomycin-resistant Enterococcus faecalis on plates with vancomycin and blocks the induction of vancomycin resistance, which involves a membrane-associated signal transduction mechanism, either at or before initiation of transcription. Given the surfactant nature of GML and the results of previous experiments, we suggest that GML blocks signal transduction. In contrast, GML has no effect on the induction of erythromycin-inducible macrolide resistance in S. aureus, which does not involve signal transduction.

References

Mar 1, 1992·Antimicrobial Agents and Chemotherapy·P M SchlievertR P Novick
Jan 1, 1982·Molecular & General Genetics : MGG·J HahnD Dubnau
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S Horinouchi, B Weisblum
Jul 1, 1996·Antimicrobial Agents and Chemotherapy·M H Lai, D R Kirsch

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Citations

Jul 17, 2007·Applied and Environmental Microbiology·Muriel DufourRobin S Simmonds
Sep 26, 2006·Journal of Food Protection·Mary Anne Roshni AmalaradjouKumar Venkitanarayanan
Jul 14, 2005·Molecular and Cellular Biochemistry·Harry G PreussThomas B Elliott
Sep 16, 2005·Journal of Dairy Science·M K M NairK S Venkitanarayanan
Oct 19, 2014·Archives of Microbiology·Yvonne NeumannSimon J Foster
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·Sara M Vetter, Patrick M Schlievert
Jan 1, 2005·Toxicology Mechanisms and Methods·Harry G PreussCass Ingram
Apr 9, 2001·The Journal of Pharmacy and Pharmacology·K Poole
Jul 13, 2000·FEMS Immunology and Medical Microbiology·L YaoF D Lowy
Mar 14, 2019·Microbial Pathogenesis·Leonardo Quintana Soares LopesRoberto Christ Vianna Santos

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