Glycerol production in rainbow smelt (Osmerus mordax) may be triggered by low temperature alone and is associated with the activation of glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase

The Journal of Experimental Biology
William R DriedzicK V Ewart

Abstract

Rainbow smelt (Osmerus mordax) accumulate high levels of glycerol in winter that serves as an antifreeze. Fish were subjected to controlled decreases in water temperature and levels of plasma glycerol, liver metabolites and liver enzymes were determined in order to identify control mechanisms for the initiation of glycerol synthesis. In two separate experiments, decreases in temperature from 8 degrees C to 0 degrees C over a period of 10-11 days resulted in increases in plasma glycerol from levels of less than 4 mmol l(-1) to approximate mean levels of 40 (first experiment) and 150 mmol l(-1) (second experiment). In a third experiment, decreases in temperature to -1 degrees C resulted in plasma glycerol levels approaching 500 mmol l(-1). The accumulation of glycerol could be driven in either December or March, thus eliminating decreasing photoperiod as a necessary cue for glycerol accumulation. Glycerol accumulation in plasma was associated with changes in metabolites in liver leading to increases in the mass action ratio across the reactions catalyzed by glycerol-3-phosphate dehydrogenase (GPDH) and glycerol-3-phosphatase (G3Pase). The maximal, in vitro activity of GPDH, increased twofold in association with a sharp increase i...Continue Reading

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Citations

Oct 12, 2012·Molecular Biology Reports·Ashoktaru BaratPrabhati K Sahoo
Jul 29, 2009·The Journal of Biological Chemistry·Jianqi YangRichard W Hanson
Feb 23, 2012·Journal of Biotechnology·Steffen N LindnerVolker F Wendisch
May 20, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jennifer R HallWilliam R Driedzic
Apr 30, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·William R Driedzic
Jul 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathy A ClowWilliam R Driedzic
Dec 28, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Delphine Ditlecadet, William R Driedzic
Dec 24, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Delphine DitlecadetWilliam R Driedzic
Feb 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathy A Clow, William R Driedzic
Jul 8, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer R HallWilliam R Driedzic
Oct 8, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Yonggang NiuQiang Chen
Aug 11, 2007·The Journal of Experimental Biology·William R Driedzic, Connie E Short
Jul 16, 2008·The Journal of Experimental Biology·Leonardo MagnoniJean-Michel Weber
Aug 21, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Robert P EvansGarth L Fletcher

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