Glycerol uptake by erythrocytes from warm- and cold-acclimated Cope's gray treefrogs.

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
David L GoldsteinCarissa M Krane

Abstract

Cope's gray treefrogs, Hyla chrysoscelis, accumulate glycerol during the period of cold acclimation that leads to the development of freeze tolerance. Glycerol must cross cell membranes in numerous processes during this time, including exit from hepatocytes where glycerol is synthesized and entry into other tissues, where glycerol is cryoprotective. Thus, we hypothesized that erythrocytes from H. chrysoscelis would be permeable to glycerol and that that permeability would be up-regulated during cold acclimation. Further, we hypothesized that glycerol permeability would be associated with the expression of aquaporins, particularly those from the glyceroporin sub-family. Erythrocytes from warm-acclimated treefrogs had high glycerol permeability at 20°C, as assessed by the time required for osmotic lysis following suspension in 0.2 M glycerol. That osmotic lysis, as well as uptake of radio-labeled glycerol, was inhibited by 0.3 mM HgCl(3). Permeability assessed via osmotic lysis was markedly reduced at 5°C. These properties were similar in animals deriving from northern (Ohio) and southern (Alabama) populations, although suggestive (through statistical interactions) of greater glycerol permeability in northern animals. Erythrocyte...Continue Reading

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Citations

Apr 30, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·William R Driedzic
May 3, 2016·The Journal of Physical Chemistry. B·Christoffer OlssonJan Swenson
Apr 2, 2019·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Loren GeissCarissa M Krane
Feb 10, 2017·Physiological Reviews·Kenneth B Storey, Janet M Storey
Jun 10, 2011·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Venkateshwar MutyamCarissa M Krane
Mar 20, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M Clara F do AmaralCarissa M Krane
Feb 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kathy A Clow, William R Driedzic

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