Glycerolipid biosynthesis in rat adipose tissue. Influence of age and cell size on substrate utilization

Lipids
S C JamdarG N Wells

Abstract

The conversion of [14C]-labeled compounds such as acetate, glucose, pyruvate and palmitate into CO2, glyceride-glycerol, glyceride fatty acids and total lipids was monitored in the average and matching adipocyte (with respect to size) preparations from young (6-9 wk) and old (age 56-60 wk) male Sprague-Dawley rats. The average cell size populations from young and old rats were 46 +/- 3 and 83 +/- 11 microns in diameter, respectively. The incorporation of [14C]acetate, pyruvate and glucose into fatty acids was significantly reduced in the adipocytes from older rats, irrespective of their sizes. The production of CO2 and glyceride-glycerol did not change significantly as a function of either cell size or animal age. Palmitate incorporation into lipids was similar in the average cell population derived from old and young rats, but it was considerably lower in the smaller adipocytes (46-50 microns diameter) from old animals. Irrespective of the cell size, triacylglycerol formation from sn-glycerol-3-phosphate was also significantly diminished in the adipocytes from older animals compared to younger ones as evidenced by decreases in activities of several enzymes, including sn-glycerol-3-phosphate acyltransferase, Mg2+-dependent phos...Continue Reading

References

Aug 15, 1976·The Biochemical Journal·S C JamdarH J Fallon
Aug 1, 1977·Archives of Biochemistry and Biophysics·S C Jamdar
Aug 1, 1970·European Journal of Clinical Investigation·P Björntorp, M Karlsson
Dec 5, 1974·European Journal of Clinical Investigation·F M HansenJ Gliemann
Oct 31, 1984·Mechanisms of Ageing and Development·N BakerK R Bruckdorfer
Jan 15, 1981·The Biochemical Journal·S C JamdarJ A Zeigler
Jun 1, 1980·Journal of Animal Science·T D Etherton, C E Allen

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Citations

Apr 6, 1995·Biochimica Et Biophysica Acta·S C Jamdar, W F Cao
Apr 1, 1997·The International Journal of Biochemistry & Cell Biology·S C Jamdar, W F Cao
Feb 8, 2003·Biochimica Et Biophysica Acta·Latha KannanChristopher A Jolly
Dec 1, 1993·Journal of the American College of Nutrition·S G HwangR Kawashima
Apr 3, 2008·Journal of Peptide Science : an Official Publication of the European Peptide Society·Jiahua YuByung-Hyun Park
Mar 19, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sebastian HaidarliuEhud Ahissar
Feb 15, 2005·Biochimica Et Biophysica Acta·Lauren W CollisonChristopher A Jolly
Aug 1, 1992·Archives of Biochemistry and Biophysics·S C Jamdar, W F Cao
Dec 1, 1989·Journal of the American Geriatrics Society·C Remacle, N Hauser
Sep 27, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C FarnierR Bazin

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