Glyceryl monooleate-coated bioadhesive hollow microspheres of riboflavin for improved gastroretentivity: optimization and pharmacokinetics

Drug Delivery and Translational Research
Mayank Shekhar Upadhyay, Kamla Pathak

Abstract

The bioadhesive hollow microspheres of riboflavin were developed as a site-specific gastroretentive system to prolong the residence time of drug in the stomach and, consequently, to enhance the bioavailability. Hollow microspheres (M1-M9) prepared by the emulsion solvent diffusion method using ethyl cellulose and Eudragit E100 as shell-forming polymers were designed using 3(2) full factorial design. The optimized formulation (M5) with 93.23 ± 0.6 % entrapment efficiency and 75.39 ± 3.4 % cumulative drug release at 8 h was subjected to coating with a bioadhesive layer of glyceryl monooleate (GMO) to obtain BM5. It exhibited excellent in vitro buoyancy for 12 h (100 %), in vitro bioadhesion (88.33 ± 2.35 %), and presented micromeritic properties amenable to processing steps. Scanning electron microscopy depicted a spherical shape and hollow cavity of microspheres and evidenced smooth surface coating of GMO. The compatibility of drug and excipients and the absence of interaction were determined using differential scanning calorimetry and diffuse reflectance spectroscopy, respectively. The in vitro release from BM5 (novel release apparatus) demonstrated that drug release was not hindered by the bioadhesive coating layer of GMO. The...Continue Reading

References

Feb 1, 1992·Journal of Pharmaceutical Sciences·Y KawashimaY Itoh
Nov 1, 1985·Pediatric Research·H M SaidD Hollander
Jan 1, 1967·Journal of Pharmaceutical Sciences·W J Jusko, G Levy
Jan 1, 1984·Journal of Pharmaceutical Sciences·I MaharajJ B Campbell
Jan 1, 1996·The American Journal of Clinical Nutrition·J ZempleniD B McCormick
May 24, 2001·The Journal of Pharmacy and Pharmacology·J LeeI W Kellaway
Apr 27, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Al-Sayed SallamIbtisam Freij
Apr 4, 2003·International Journal of Pharmaceutics·Jaspreet Kaur VasirSanjay Garg
May 20, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yasunori SatoHiromitsu Yamamoto
Mar 17, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yasunori SatoHiromitsu Yamamoto
Mar 17, 2004·International Journal of Pharmaceutics·Kiran Kumar MAnant Paradkar
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhepeng LiuJun Pan
Jun 30, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Leonid KaganAmnon Hoffman
Sep 28, 2006·Methods and Findings in Experimental and Clinical Pharmacology·J AliM Ali
Sep 2, 2008·International Journal of Pharmaceutics·Huimin YaoSanming Li

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Citations

Jul 5, 2015·International Journal of Pharmaceutics·Vilas N MalodePadma V Devarajan
Feb 11, 2015·Clinical Pharmacokinetics·Kamla Pathak, Smita Raghuvanshi
Feb 27, 2016·Journal of Biomaterials Applications·Pei ZhangChen-Guang Liu

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