PMID: 8958795Nov 1, 1996Paper

Glyceryl trinitrate enhances nitric oxide mediated perfusion within the equine hoof

The Journal of Endocrinology
K A HinckleyI W Henderson

Abstract

Laminitis, a microvascular disease of the equine hoof leads to severe lameness. Exogenous iv 1-arginine and transdermal nitric oxide donors, such as GTN, applied to the pasterns improve lameness during acute laminitis. Near Infrared spectroscopy in an earlier study showed haemostasis and ischaemia in the hoof during acute laminitis, both were alleviated by 1-arginine. Quantitative NIRS in the present study shows that transdermal GTN increases blood flow in the equine hoof. It is concluded that glyceryl trinitrate enhances nitric oxide mediated perfusion within the equine hoof in normal and chronically laminitic horses and ponies.

Citations

May 16, 2002·American Journal of Veterinary Research·Tracy K HoffIlka P Wagner
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·Y BerhaneS R Bailey
Oct 31, 2012·Equine Veterinary Journal·N Menzies-Gow
Jan 8, 2005·The Veterinary Clinics of North America. Equine Practice·Philip J Johnson
Jan 27, 2004·The Veterinary Clinics of North America. Equine Practice·Thomas J Divers
Feb 15, 2001·Veterinary Surgery : VS·L M Howe, H W Boothe
Jun 15, 2006·The Journal of Nutrition·Patricia HarrisAnnette Longland

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