Glycerylphytate compounds with tunable ion affinity and osteogenic properties

Scientific Reports
Ana Mora-BozaJulio San Román

Abstract

Phytic acid (PA) is a natural-occurring antioxidant, which plays an important role in many biological processes. PA is recognized as a potent inhibitor of lipid peroxidation because of its high affinity to multivalent cations, and it can play a role in osteogenic processes. However, its powerful chelating capacity is controversial because it can lead to a severe reduction of mineral availability in the organism. For this reason, compounds with beneficial biological properties of PA, but a modular ion binding capacity, are of high interest. In this work, we report the synthesis and physicochemical characterization of two hydroxylic derivatives of PA, named glycerylphytates (GPhy), through a condensation reaction of PA with glycerol (G). Both derivatives present antioxidant properties, measured by ferrozine/FeCl2 method and chelating activity with calcium ions depending on the content of glyceryl groups incorporated. Besides, the hydroxylic modification not only modulates the ion binding affinity of derivatives but also improves their cytocompatibility in human bone marrow mesenchymal cells (MSCs). Furthermore, GPhy derivatives display osteogenic properties, confirmed by COL1A and ALPL expression depending on composition. These p...Continue Reading

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Citations

Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ana Mora-BozaJulio San Román
May 1, 2021·Polymers·María Puertas-BartoloméLuis García-Fernández
May 4, 2021·Comprehensive Reviews in Food Science and Food Safety·Frank SangijaAthanasia Matemu

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Methods Mentioned

BETA
Nuclear Magnetic Resonance
NMR
Differential Scanning Calorimetry
MDA
Assay
PCR

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