Glycine at the gate--from model to mechanism

Neuron
Jing Zhao, John N Wood

Abstract

In this issue of Neuron, Foster et al. (2015) show that ablating, silencing, or activating spinal glycinergic inhibitory neurons with viral vectors all have dramatic effects on pain and itch. These results provide molecular insights into pain gate control and useful tools for the rapid analysis of other CNS circuits.

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