Glycine blocks long-term potentiation of GABAergic synapses in the ventral tegmental area

Neuroscience
Yanzhong Guan, Jiang-Hong Ye

Abstract

The mesocorticolimbic dopamine system, originating in the ventral tegmental area (VTA) is normally constrained by GABA-mediated synaptic inhibition. Accumulating evidence indicates that long-term potentiation of GABAergic synapses (LTPGABA) in VTA dopamine neurons plays an important role in the actions of drugs of abuse, including ethanol. We previously showed that a single infusion of glycine into the VTA of rats strongly reduces ethanol intake for 24h. In the current study, we examined the effect of glycine on the electrophysiological activities of putative dopamine VTA neurons in midbrain slices from ethanol-naïve rats. We report here that a 15-min exposure to 10 μM glycine prevented trains of high-frequency stimulation (HFS) from producing LTPGABA, which was rescued by the glycine receptor (GlyR) antagonist strychnine. Glycine also concentration-dependently decreased the frequency of spontaneous excitatory postsynaptic currents (sEPSCs). By contrast, glycine pretreatment did not prevent potentiation of inhibitory postsynaptic currents (IPSCs) during a continuous exposure to the nitric oxide (NO) donor, SNAP (S-nitroso-N-acetylpenicillamine), or a brief exposure to 10 μM glycine and 10 μM NMDA (N-methyl-D-aspartate), an agon...Continue Reading

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Citations

Oct 26, 2016·Neurotoxicity Research·Verónica PastorMaría Eugenia Pallarés
May 8, 2018·The European Journal of Neuroscience·Salma A Quraishi, Carlos A Paladini
Aug 24, 2017·Alcoholism, Clinical and Experimental Research·Bo SöderpalmMia Ericson
Sep 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Skylar Y Cooper, Brandon J Henderson

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