PMID: 8582053Oct 1, 1995Paper

Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function

Clinical Biochemistry
Katryn N FuruyaL Ellis

Abstract

To evaluate glycine conjugation of para-aminobenzoic acid (PABA) to the hippurated metabolites, para-aminohippuric acid (PAHA), and para-acetamidohippuric acid (PAAHA) as a quantitative liver function test in patients with liver disease. Serum concentrations of PABA and metabolites were measured by high pressure liquid chromatography in 24 controls and 50 patients with hepatobiliary disease. Hippurate formation was significantly decreased in all patient groups with chronic liver disease versus controls. The hippurate ratio (% hippurated metabolites formed) correlated with severity of disease, serum albumin, and factor VII concentrations. PAHA concentration was a better prognostic indicator than factor VII concentrations in patients with acute liver disease; concentrations of zero correctly predicted a poor outcome in patients with fulminant liver failure. Glycine conjugation of PABA may be useful as a quantitative liver function test in patients with hepatobiliary disease and as a prognostic index in patients with fulminant liver failure.

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Citations

Apr 28, 2012·SAR and QSAR in Environmental Research·O MekenyanS Kotov
Apr 13, 2007·Expert Opinion on Drug Metabolism & Toxicology·Kathleen M KnightsJohn O Miners
Apr 24, 2014·Drug Metabolism Reviews·Christoffel Petrus Stephanus BadenhorstAlberdina Aike van Dijk
Sep 17, 2011·The Journal of Surgical Research·Jai BikhchandaniAshley Dennison
Oct 21, 2015·Journal of Biochemical and Molecular Toxicology·Carla NortjeElardus Erasmus
Jun 24, 2005·American Journal of Surgery·Emma J MullinGuy J Maddern
May 9, 2013·Expert Opinion on Drug Metabolism & Toxicology·Christoffel Petrus Stephanus BadenhorstAlberdina Aike van Dijk
Dec 31, 2005·Journal of Pediatric Gastroenterology and Nutrition·Diana R MagerEve A Roberts
Dec 25, 2002·Journal of Pediatric Gastroenterology and Nutrition·Sylvie LebelKatryn N Furuya

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