Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats

Biochemical and Biophysical Research Communications
Long-Hua ZhangTian-Le Xu

Abstract

Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their roles in synaptic transmission are unclear. In this study, we examined the effect of GlyR activation on paired-pulse stimulation of the whole-cell postsynaptic currents (PSCs) in the Schaffer-CA1 synapses in rat hippocampal slices. Bath application of glycine reduced the amplitude of PSCs, accompanied by an increase in holding current and resting conductance. Moreover, glycine application increased the paired-pulse ratio (PPR) of PSCs significantly, an effect largely abolished by the GlyR specific antagonist strychnine. Interestingly, glycine application had no significant effect on either the amplitude or the PPR of excitatory postsynaptic currents (EPSCs). Our findings suggest that GlyR activation regulates hippocampal short-term plasticity by altering GABAergic neurotransmission.

References

Jan 1, 1989·Annual Review of Neuroscience·R S Zucker
Dec 1, 1994·Trends in Neurosciences·I ModyI Soltesz
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jan 10, 1997·Science·L F AbbottS B Nelson
Oct 1, 1998·Neurobiology of Learning and Memory·H MarkramM Tsodyks
Jun 9, 2000·Annual Review of Neuroscience·S J MartinR G Morris
Jun 19, 2001·Trends in Neurosciences·E S Fortune, G J Rose
May 14, 2003·Neuron·Simon J Mitchell, R Angus Silver
Apr 14, 2004·The European Journal of Neuroscience·Jörg BreustedtVolker Schmieden
Oct 16, 2004·Biochemical and Biophysical Research Communications·Marian BrackmannKarl-Heinz Braunewell
Nov 24, 2004·Molecular and Cellular Neurosciences·Lydia DanglotAlain Bessis
Jun 9, 2005·Brain Research. Developmental Brain Research·Xuehua SunLin Xu

❮ Previous
Next ❯

Citations

Jul 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tara KeckJohn A White
Sep 19, 2012·The Journal of Physiology·Portia A KunzBenjamin D Philpot
Sep 13, 2008·Brain Research·Zeng-You YeJiang-Ning Zhou
Jul 26, 2016·Frontiers in Molecular Neuroscience·Kazutoyo Ogino, Hiromi Hirata
Dec 29, 2007·Molecular Pharmacology·Xiao-Bing ZhangTian-Le Xu
Jun 17, 2009·Reviews in the Neurosciences·Tara Keck, John A White

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.