Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies

Stroke; a Journal of Cerebral Circulation
K TakanoM Fisher

Abstract

The glycine site on the N-methyl-D-aspartate (NMDA) receptor complex offers a therapeutic target for acute focal ischemia, potentially devoid of most side effects associated with competitive and noncompetitive NMDA antagonists. A novel glycine receptor antagonist, ZD9379, was studied in 70 Sprague-Dawley rats using the suture occlusion model of permanent middle cerebral artery occlusion (MCAO). In the first experiment, 20 rats received an initial bolus of vehicle or 10 mg/kg ZD9379 (n = 10 in each group) 30 minutes after MCAO, followed by a continuous infusion of the same dose per hour for 4 hours. Diffusion-weighted MRI with echo-planar acquisition was used to generate maps of the apparent diffusion coefficient (ADC) of water. In a second experiment, 50 rats were assigned to five groups: vehicle and 10, 5, 2.5, and 1 mg/kg ZD9379 (n = 10 in each group) with the same dosing protocol but no imaging. In both experiments, infarct volume was determined by 2,3,5-triphenyltetrazolium chloride staining. In the first experiment, before therapy was begun, there was no significant difference in ADC-derived ischemic lesion volume between the two groups. Over time, the 10-mg/kg ZD9379-treated rats had a significant delayed regional recover...Continue Reading

References

May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R GillH Hagberg
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L DezsiM Reivich
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T IijimaK A Hossmann
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A SwansonF R Sharp
Jun 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J DelannoyD Le Bihan
Mar 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J MintorovitchP R Weinstein
Jul 9, 1990·Brain Research·B GottiB Scatton
May 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M E MoseleyP R Weinstein
Oct 1, 1988·Annals of Neurology·C K ParkJ McCulloch
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E OzyurtJ McCulloch
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C K ParkJ McCulloch
Feb 9, 1988·Brain Research·C P GeorgeG K Steinberg
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R BustoM D Ginsberg
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Hoehn-BerlageK A Hossmann
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D S WarnerE Weber
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R GillJ A Kemp
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E H LoD Luttinger
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y HasegawaM Fisher
Jan 1, 1993·Trends in Pharmacological Sciences·J A Kemp, P D Leeson
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B J DardzinskiK Minematsu
Dec 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M Hoehn-BerlageK Yamashita

❮ Previous
Next ❯

Citations

Feb 26, 2005·Psychopharmacology·James N C Kew, John A Kemp
Apr 12, 2000·European Journal of Medicinal Chemistry·T W Stone
Feb 6, 2004·Chemical & Pharmaceutical Bulletin·Shinji AbeToshiaki Tamaki
Mar 1, 2010·Translational Stroke Research·Guang JinEng H Lo
Oct 3, 2006·Current Opinion in Anaesthesiology·D K Menon, A C Summors
Jan 5, 2001·Expert Opinion on Investigational Drugs·M E Tranquillini, A Reggiani
Apr 3, 2001·Expert Opinion on Investigational Drugs·T W Stone
Jul 14, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y LiuH J Aronen
Sep 16, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Daniel StrbianPerttu J Lindsberg
May 25, 2007·Pharmacology, Biochemistry, and Behavior·Aysan Durukan, Turgut Tatlisumak
Aug 13, 2005·Acta Anaesthesiologica Scandinavica·R Y GundersenP K Opstad
Jan 18, 2012·The FEBS Journal·Trevor W StoneL Gail Darlington
Apr 11, 2000·Neurologic Clinics·P J LindsbergM Kaste
Oct 17, 2002·Emergency Medicine Clinics of North America·Dexter L MorrisJ Stephen Huff
Feb 24, 2009·Experimental Neurology·Guang JinEng H Lo
Oct 31, 2002·Nature Reviews. Drug Discovery·Trevor W Stone, L Gail Darlington
Oct 29, 2004·Journal of Medicinal Chemistry·M Encarnación CamachoAntonio Espinosa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
F Dumont, G Slegers
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Feng XiaoSteven A Conrad
© 2021 Meta ULC. All rights reserved