Glyco-genes change expression in cancer through aberrant methylation

Biochimica Et Biophysica Acta
Aleksandar VojtaVlatka Zoldoš

Abstract

Most eukaryotic proteins are modified by covalent addition of glycan molecules that considerably influence their function. Aberrant glycosylation is profoundly involved in malignant transformation, tumor progression and metastasis. Some glycan structures are tumor-specific and reflect disturbed glycan biosynthesis pathways. We analyzed DNA methylation and expression of 86 glyco-genes in melanoma, hepatocellular, breast and cervical cancers using data from publicly available databases. We also analyzed methylation datasets without the available matching expression data for glyco-genes in lung cancer, and progression of melanoma into lymph node and brain metastases. Ten glyco-genes (GALNT3, GALNT6, GALNT7, GALNT14, MGAT3, MAN1A1, MAN1C1, ST3GAL2, ST6GAL1, ST8SIA3) showing changes in both methylation and expression in the same type of cancer belong to GalNAc transferases, GlcNAc transferases, mannosidases and sialyltransferases, which is in line with changes in glycan structures already reported in the same type of tumors. Some of those genes were additionally identified as potentially valuable for disease prognosis. The MGAT5B gene, so far identified as specifically expressed in brain, emerged as a novel candidate gene that is ep...Continue Reading

References

Mar 28, 2001·Science·A Helenius, M Aebi
Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
May 6, 2003·Gastroenterology·Pierre Laurent-PuigJessica Zucman-Rossi
Aug 5, 2003·Molecular and Cellular Biology·Ralph SeidenfadenHerbert Hildebrandt
Mar 17, 2005·Breast Cancer Research and Treatment·Sylvain JulienPhilippe Delannoy
Oct 11, 2008·Nature Reviews. Immunology·Jamey D Marth, Prabhjit K Grewal
Jan 23, 2009·Journal of Hepatology·Bram BlommeHans Van Vlierberghe
Apr 8, 2009·Molecular and Cellular Biology·Erica L StoneJamey D Marth
Apr 28, 2009·BMC Medical Genomics·Hideaki MizunoAkinori Sarai
Dec 5, 2009·Clinical Chemistry·Penelope M DrakeSusan J Fisher
Jan 26, 2010·Pathology, Research and Practice·Ivyna Bong Pau NiSharifah Noor Akmal Syed Hussain
Nov 26, 2010·Molecular & Cellular Proteomics : MCP·Maria Lorna A de LeozCarlito B Lebrilla
Jan 11, 2011·Journal of Proteome Research·James N ArnoldPauline M Rudd
Jun 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ying-Chih LiuChi-Huey Wong
Nov 17, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Radka SaldovaPauline M Rudd
Dec 24, 2011·Biochimica Et Biophysica Acta·Tomislav HorvatVlatka Zoldoš
Mar 20, 2012·Trends in Molecular Medicine·Shigeru TsuboiMinoru Fukuda
Apr 12, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anand MehtaTimothy Block
Jun 19, 2012·Clinical Epigenetics·Tomislav HorvatGordan Lauc
Jun 23, 2012·Nature Reviews. Molecular Cell Biology·Kelley W MoremenAlison V Nairn
Jul 12, 2012·Glycobiology·Jacqueline A VasseurMilos V Novotny
Sep 11, 2012·Cancer Prevention Research·Hiroyuki TakamaruYasuhisa Shinomura
Nov 9, 2012·Clinical Chemistry·Nora BeroisEduardo Osinaga
Dec 5, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Jing ShenRegina M Santella
Sep 4, 2013·Biochimica Et Biophysica Acta·Gordan LaucVlatka Zoldoš

❮ Previous
Next ❯

Citations

May 3, 2016·Biomolecules·Yasuhiko Kizuka, Naoyuki Taniguchi
Jul 26, 2016·Frontiers in Oncology·Leonardo Marques da FonsecaMárcia Alves Marques Capella
Mar 21, 2017·Oncogenesis·A Vasconcelos-Dos-SantosA R Todeschini
May 10, 2017·International Journal of Molecular Sciences·Fabio Dall'Olio, Marco Trinchera
Jul 23, 2019·FEBS Letters·Prathyush PothukuchiSeetharaman Parashuraman
Mar 24, 2016·Oncotarget·Jennifer Munkley, David J Elliott
Mar 13, 2019·Nature Reviews. Nephrology·Colin ReilyJan Novak
Jul 7, 2020·Frontiers in Cell and Developmental Biology·Xinyue HuXing Yu
Feb 3, 2019·Cancer Research·Isabelle AtkinsRichard S Houlston
Dec 16, 2020·Glycobiology·Kaitlyn A DorsettSusan L Bellis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.