Glycocalyx shedding is markedly increased during the acute phase of Takotsubo cardiomyopathy

International Journal of Cardiology
Thanh H NguyenJohn D Horowitz

Abstract

Acute myocardial infarction (AMI) and other forms of myocardial acute oxidative stress are associated with variable "shedding" of the endothelial glycocalyx (GCS) which can be quantitated ex vivo by release into plasma of glycocalyx components such as Syndecan-1 (SD-1). Previous studies have implicated release of both catecholamines and BNP as potential accentuating factors in GCS: since these are prominent aspects of the pathogenesis of Takotsubo cardiomyopathy (TTC), we hypothesised that TTC is associated with increased GCS and the extent of GCS is predictable on the basis of NT-proBNP and catecholamine releases. SD-1 concentrations were measured in 48 TTC patients acutely and after 3months, and compared with those in 12 healthy controls, and 17 patients with AMI. Correlations were sought between SD-1 levels markers of severity of TTC episodes in individual patients. Acute SD-1 concentrations in TTC patients were elevated significantly (p<0.0001, 1-way ANOVA) compared to control values. There were no significant correlations between SD-1 concentrations and any markers of severity of acute TTC episodes, such as NT-proBNP or catecholamine release. Over 3months, SD-1 concentrations fell significantly (p=0.0002) to approximately ...Continue Reading

Citations

Jun 23, 2018·British Journal of Pharmacology·Jessica Bertrand, Miriam Bollmann
Aug 8, 2018·Cardiovascular Research·John D Horowitz, Saifei Liu
Jan 7, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Mathias Alexander HøjagergaardMartin Frydland
Aug 1, 2018·JACC. Basic to Translational Science·Sven Y SurikowJohn D Horowitz
Jan 23, 2021·Heart & Lung : the Journal of Critical Care·Keerat Rai AhujaJohn E Madias
Feb 18, 2021·Acta Anaesthesiologica Scandinavica·Robert G HahnRandal O Dull
Mar 25, 2021·ESC Heart Failure·Gao Jing OngJohn David Horowitz
Apr 12, 2020·Trends in Cardiovascular Medicine·Andra Maria Ciutac, Dana Dawson
Apr 29, 2020·Trends in Cardiovascular Medicine·Thanh H NguyenJohn D Horowitz
Apr 16, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jinxi LiuShuxia Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.