Mar 1, 1987

Glycoconjugate synthesis during early pregnancy: hyaluronate synthesis and function

Developmental Biology
D D CarsonJ P Tang

Abstract

The synthesis of various glycoconjugate classes by mouse uteri during the pre- and peri-implantation period has been examined using [3H]glucosamine as a metabolic precursor. A unique and dramatic (five- to sixfold) increase was observed in the synthesis of hyaluronate on the day upon which embryo implantation normally occurs. Mated, but nonpregnant mice did not display increased hyaluronate biosynthesis. In contrast to hyaluronate, the synthesis of most other types of glycoconjugates remained fairly constant during the first 5 days of pregnancy. Low (1500-5000)-molecular-weight N-linked oligosaccharides constituted the major class of oligosaccharides synthesized under all conditions. High (greater than 10,000)-molecular-weight glycoconjugates constituted the second most abundant class of glycoconjugates synthesized (20-30%). Most (85%) of the newly synthesized hyaluronate was associated with the nonepithelial cell types of the uterus. Experiments using ovariectomized mice receiving steroid hormones demonstrated that uterine hyaluronate synthesis was induced preferentially by an artificial decidual stimulus and implicated stromal cells as the site of hyaluronate synthesis. In addition, it was demonstrated that tissue culture pla...Continue Reading

  • References12
  • Citations40

Mentioned in this Paper

Embryo
Metabolic Process, Cellular
Glycosaminoglycans
Entire Uterus
Neoplasm of Uncertain or Unknown Behavior of Uterus
Endometrium
Uterus
Glycopeptides
Epithelium
Blastocyst Implantation, Natural

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