Glycoconjugates in normal wound tissue matrices during the initiation phase of limb regeneration in adult Ambystoma

The Anatomical Record
H E YoungR R Markwald

Abstract

The present study identifies, localizes, and reports the relative composition of specific glycosaminoglycans within tissue matrices during the initiation phase of limb regeneration. The regenerate tissues were harvested and assayed morphologically, histochemically, and chemically. We observed 1) a population of cells interspersed among the cells of the dermis, epimysium, perimysium, perichondrium, and periosteum. 2) This population was distinguishable by a unique pattern of glycoconjugate staining, i.e., intracellular and pericellular heparan sulfate and glycoproteins and extracellularly associated hyaluronate and glycoproteins. 3) Cells with these staining characteristics aggregated to a position directly beneath the apical epidermal cap. 4) Extracellular hyaluronate and glycoproteins colocalized with undifferentiated tissues. And 5) extracellular chondroitin sulfate, dermatan sulfate, and keratan sulfate glycosaminoglycans colocalized with differentiated tissues. The correlations of distinct glycoconjugate compositions with specific regeneration morphologies suggest the possibility that these components may be related to the phenotypic expression of tissues during regeneration.

References

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Citations

Dec 29, 2010·PloS One·Wolfgang Pita-ThomasManuel Nieto-Diaz
Sep 1, 1993·In Vitro Cellular & Developmental Biology. Animal·H E YoungP A Lucas
Dec 31, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Henry E Young, Asa C Black
Feb 26, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Henry E YoungAsa C Black
Feb 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H E YoungP A Lucas
Sep 1, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jihong CuiFulin Chen
Dec 15, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jeffrey T Laitman, Kurt H Albertine

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