Glycodelin A suppresses the cytolytic activity of CD8+ T lymphocytes

Molecular Immunology
Chetna Soni, Anjali A Karande

Abstract

Maternal tolerance to the semi-allogenic fetus is brought about by several mechanisms in humans. Glycodelin A (GdA), secreted by the uterine mucosa and decidua is induced to high levels by progesterone between 12 and 16 weeks of pregnancy. The glycoprotein, an immunomodulator has been shown to be inhibitory to the survival and functions of almost all the immune cells. CD8(+) T cells which predominate the T lymphocyte population in the decidua are relatively less studied. We attempted to find out the possible mechanism, if any, of regulation of the cytolytic function of CD8(+) T cells during pregnancy. Alloactivated CD8(+) T cells harbouring specific cytolytic activity against target cells exhibited compromised activity upon treatment with high concentrations of GdA. Interestingly, unlike the CD4(+) T cells, CD8(+) T cells were resistant to GdA-induced apoptosis. The inhibition of cytotoxic T lymphocyte activity was brought about by the downregulation of transcription of the cytolytic effector molecules, granzyme B and perforin and the degranulation of cytolytic vesicles. These results suggest a protective role played by GdA during pregnancy by regulating the cytolytic activity of CD8(+) T cells.

Citations

Dec 3, 2013·Progress in Biophysics and Molecular Biology·Berthold HuppertzJayasree Sengupta
Dec 24, 2011·Autoimmunity Reviews·Grant C Hughes
Jun 7, 2011·Journal of Reproductive Immunology·Cheuk-Lun LeePhilip C N Chiu
Feb 5, 2011·The Journal of Pathology·Giovanna OggéChong Jai Kim
Apr 24, 2014·American Journal of Reproductive Immunology : AJRI·Koji Yoshinaga
Mar 31, 2015·Journal of Reproductive Immunology·André SchmidtUdo R Markert
Apr 5, 2014·Medical Hypotheses·Donna L Schminkey, Maureen Groer
Mar 8, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Tukki SarkarAkhtar Hussain
Dec 23, 2017·Clinical and Experimental Immunology·A DixitA A Karande
Dec 10, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Samya BanerjeeAkhil R Chakravarty
Dec 15, 2017·Frontiers in Immunology·Juan CuiXiuwen Wang
Jun 12, 2017·Journal of Inorganic Biochemistry·Arun KumarAkhil R Chakravarty
Aug 4, 2021·International Journal of Sports Medicine·Polina M KrassovskaiaNicholas T Broskey

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