Glycodelin reduces breast cancer xenograft growth in vivo

International Journal of Cancer. Journal International Du Cancer
L HautalaH Koistinen

Abstract

Malignant growth is characterized by loss of cell differentiation, uncontrolled proliferation and resistance to apoptosis. Many tumor suppressor genes that protect cells against malignant transformation regulate cell differentiation. Here, we show for the first time that glycodelin, a differentiation-related protein, reduces breast cancer tumor growth in vivo. We found that glycodelin cDNA-transfected MCF-7 breast cancer cells showed a differentiated phenotype and produced smaller tumors in mouse mammary fat pads compared with control-transfected cells. Glycodelin-induced differentiation was associated with reduced expression of oncogenes and increased expression of tumor suppressor genes. Our results suggest that glycodelin acts as a tumor suppressor in breast cancer. This may explain its reported association with a more favorable prognosis in some cancers.

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Citations

Jun 25, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Hannu KoistinenRiitta Koistinen
Apr 17, 2012·Reproductive Biomedicine Online·Kam-Hei SoKai-Fai Lee
Oct 6, 2009·Journal of Cellular and Molecular Medicine·Suping RenAdam I Riker
Oct 18, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alessandro PalaGiuseppe Benagiano
Dec 15, 2017·Frontiers in Immunology·Juan CuiXiuwen Wang
Mar 25, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Laura C HautalaHannu Koistinen
Jun 8, 2021·Frontiers in Physiology·Lindsay Sawyer

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