Glycodendron-rhenium complexes as luminescent probes for lectin sensing

Organic & Biomolecular Chemistry
Alessandro PalmioliAnna Bernardi

Abstract

The design, synthesis and characterization of novel glycoconjugate luminescent probes based on dinuclear rhenium(i) complexes are reported. A multivalent platform bearing different carbohydrate moieties (Glc, Gal and Man) was used to target carbohydrate-binding proteins (lectins), exploiting the unique photophysical characteristics of a Re(i) luminophore for protein sensing. Our results show that these glycoconjugates, non-luminescent in aqueous medium, are able to specifically bind different lectins (ConA and PNA) with a consequent enhancement of emission intensity. These findings suggest the use of Re(i)-based glycoconjugates as switch-on luminescent probe tools in biological applications.

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Citations

Jun 20, 2019·Chembiochem : a European Journal of Chemical Biology·Alessandro PalmioliCristina Airoldi
Jan 10, 2020·Chemical Society Reviews·Baptiste ThomasSébastien Vidal
Apr 13, 2021·Bioorganic Chemistry·Alessandro PalmioliCristina Airoldi
Jul 3, 2021·Inorganic Chemistry·Todd A GillamSally E Plush

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Methods Mentioned

BETA
glycosylation
NMR
column chromatography

Software Mentioned

GraphPad Prism

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