Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions

European Journal of Medicinal Chemistry
A Prasanth SaraswatiAhmed Kamal

Abstract

Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase which is ubiquitously expressed and is regarded as a regulator for various cellular events and signalling pathways. It exists in two isoforms, GSK-3α and GSK-3β and can phosphorylate a wide range of substrates. Aberrancy in the GSK-3 activity can lead to various diseases like Alzheimer's, diabetes, cancer, neurodegeneration etc., rendering it an attractive target to develop potent and specific inhibitors. The present review focuses on the recent developments in the area of GSK-3 inhibitors and also enlightens its therapeutic applicability in various disease conditions.

Citations

Mar 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela HulcováLucie Cahlíková
May 22, 2018·Organic & Biomolecular Chemistry·Zhimin YangZhengying Pan
Jun 6, 2019·Expert Opinion on Drug Discovery·Juan F GonzálezJose María Sánchez-Montero
Oct 5, 2018·Journal of Biomedical Science·Yu-Ting WengYijuang Chern
Jan 18, 2019·Nature Communications·Dail E ChapmanSteven P Gross
Mar 23, 2019·Malaria Journal·Andreas MaschConrad Kunick
May 28, 2020·International Journal of Molecular Sciences·Runxuan LinPatrick Kwan
Jun 7, 2020·Cells·Takahiro DomotoToshinari Minamoto
Jun 14, 2019·Neural Plasticity·Tomasz JaworskiKatarzyna Gralec
Sep 26, 2019·American Journal of Physiology. Cell Physiology·Mahboubeh S NooriDouglas J Goetz
Mar 3, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Huixian LiWeiping Cheng
May 22, 2020·JCI Insight·Hemn MohammadpourPhilip L McCarthy
Aug 10, 2019·Oxidative Medicine and Cellular Longevity·Natalia Robledinos-AntónAntonio Cuadrado
Nov 21, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Matthew Goff, Guoxun Chen
Dec 23, 2019·European Journal of Medicinal Chemistry·Cun-Jian ShiXiao-Bing Wang
Jan 23, 2021·Journal of Medicinal Chemistry·Zhouling XieChenzhong Liao
Dec 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Romain MustièreNicolas Primas
Feb 13, 2021·Cells·Ido Rippin, Hagit Eldar-Finkelman
May 28, 2019·Cancer Letters·Ying LiuJianxun Wang
Feb 24, 2021·Pharmaceutical Research·William D Hedrich, Hongbing Wang
Feb 22, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Cheng ChangSheng-Na Han
Apr 8, 2019·Biochemical and Biophysical Research Communications·Jie ZhouShaojun Peng
Sep 18, 2020·European Journal of Pharmacology·Miguel Vaz, Samuel Silvestre
Jun 3, 2021·International Journal of Molecular Sciences·Weixia ZhongNissar A Darmani
Jun 3, 2021·International Journal of Molecular Sciences·Laia LidónRosalina Gavín
Aug 9, 2020·Aging and Disease·Wei-Xing MaLiang-Jun Yan
Mar 20, 2019·Journal of Chemical Information and Modeling·Hsin-Yi ChenCalvin Yu-Chian Chen
Aug 31, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Camilla PecoraroElisa Giovannetti
Dec 4, 2021·Journal of Hematology & Oncology·S VerbekeA Italiano

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