Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway

PloS One
Atsushi Sato, Hiroshi Shibuya

Abstract

The with no lysine (WNK) protein kinase family is conserved among many species. Some mutations in human WNK gene are associated with pseudohypoaldosteronism type II, a form of hypertension, and hereditary sensory and autonomic neuropathy type 2A. In kidney, WNK regulates the activity of STE20/SPS1-related, proline alanine-rich kinase and/or oxidative-stress responsive 1, which in turn regulate ion co-transporters. The misregulation of this pathway is involved in the pathogenesis of pseudohypoaldosteronism type II. In the neural system, WNK is involved in the specification of the cholinergic neuron, but the pathogenesis of hereditary sensory and autonomic neuropathy type 2A is still unknown. To better understand the WNK pathway, we isolated WNK-associated genes using Drosophila. We identified Glycogen synthase kinase 3ß (GSK3ß)/Shaggy (Sgg) as a candidate gene that was shown to interact with the WNK signaling pathway in both Drosophila and mammalian cells. Furthermore, GSK3ß was involved in neural specification downstream of WNK. These results suggest that GSK3ß/Sgg functions as a positive effector in the WNK signaling pathway.

References

Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Sep 12, 2000·Oncogene·A M JohnstonH J DeAizpurua
Aug 11, 2001·Science·F H WilsonR P Lifton
Oct 2, 2001·Science's STKE : Signal Transduction Knowledge Environment·J R Woodgett
Jul 19, 2002·Current Biology : CB·Daniel R FoltzJeffrey S Nye
Sep 30, 2004·Annals of Neurology·Jean-Baptiste RivièreGuy A Rouleau
Nov 3, 2005·The Journal of Biological Chemistry·Tetsuo MoriguchiHiroshi Shibuya
Sep 1, 2006·Neurochemical Research·Richard S JopeEléonore Beurel
Aug 5, 2009·Brain : a Journal of Neurology·Annelies RotthierVincent Timmerman
Jan 23, 2010·Cellular and Molecular Life Sciences : CMLS·Sónia Moniz, Peter Jordan
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Szu-wei TuMelanie H Cobb
Feb 6, 2013·PloS One·Atsushi Sato, Hiroshi Shibuya
Jun 26, 2013·EMBO Reports·Ekatherina SeryshevaAndreas Jenny
Jun 17, 2014·Oncotarget·James A McCubreyMelchiorre Cervello
Mar 31, 2016·Science Signaling·Kristopher T KahleGuy A Rouleau

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