Glycogen synthase kinase-3beta gene is associated with antidepressant treatment response in Chinese major depressive disorder

The Pharmacogenomics Journal
S-J TsaiT-J Chen

Abstract

Evidence suggests that glycogen synthase kinase-3beta (GSK3B) activity is increased significantly in the brain of patients with major depressive disorders (MDD). Inhibition of GSK3B is thought to be a key feature in the therapeutic mechanism of antidepressants. To investigate whether common genetic variants in the GSK3B gene are associated with MDD and the therapeutic response to antidepressants, four polymorphisms (rs334558 (-50 T>C), rs13321783 (IVS7+9227 A>G), rs2319398 (IVS7+11660 G>T) and rs6808874 (IVS11+4251 T>A)) of the GSK3B gene were genotyped in 230 Chinese MDD patients and 415 controls. Among the MDD patients, 168 accepted selective serotonin reuptake inhibitor (SSRI) (fluoxetine or citalopram) antidepressant treatment and therapeutic evaluation for 4 weeks and 117 for 8 weeks. Significant association with MDD was not shown in the alleles and genotypes of single loci or four-locus haplotypes. However, three of the four polymorphisms investigated were significantly associated with 4-week antidepressant therapeutic effect (P=0.002-0.011). Of the four-locus haplotype analysis, the GSK3B TAGT carriers showed a poorer response to antidepressants in 4-week (P<0.0001) and 8-week (P=0.015) evaluation compared with other hap...Continue Reading

References

Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S Klein, D A Melton
Mar 17, 2001·Nature Reviews. Genetics·L R Cardon, J I Bell
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Jul 2, 2002·Journal of Neurochemistry·Lian MaiXiaohua Li
Aug 16, 2002·Bipolar Disorders·Carrol D'Sa, Ronald S Duman
Oct 9, 2002·The International Journal of Neuropsychopharmacology·Bernard Lerer, Fabio Macciardi
Mar 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohua LiRichard S Jope
Apr 23, 2004·Trends in Biochemical Sciences·Richard S Jope, Gail V W Johnson
Aug 19, 2004·The International Journal of Neuropsychopharmacology·Todd D GouldHusseini K Manji
Nov 30, 2005·Annals of Neurology·John B J KwokPeter R Schofield

❮ Previous
Next ❯

Citations

Jul 14, 2012·European Child & Adolescent Psychiatry·Ana BlazquezLuisa Lázaro
Feb 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sibah HasanPaul Franken
Jul 30, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohua Li, Richard S Jope
Aug 26, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ying-Jay LiouChen-Jee Hong
Dec 2, 2014·Pharmacology & Therapeutics·Eleonore BeurelRichard S Jope
Jan 15, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Shusuke NumataTetsuro Ohmori
Jan 21, 2014·Aquatic Toxicology·Peter D HazeltonRobert B Bringolf
Jul 1, 2009·Pharmacology & Therapeutics·Sonja Horstmann, Elisabeth B Binder
Sep 30, 2014·Neuroscience and Biobehavioral Reviews·Syed Mohammed Qasim HussainiMi-Hyeon Jang
Jul 16, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chiara FabbriAlessandro Serretti
Jan 22, 2011·Psychiatry Investigation·Shih-Jen TsaiYing-Jay Liou
Feb 9, 2016·CNS Neuroscience & Therapeutics·Yun WangXue-Chu Zhen
Nov 30, 2018·Frontiers in Pharmacology·Nicolas B SeneseJohn R Traynor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.