Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Salvatore CuzzocreaChristoph Thiemermann

Abstract

Recently, glycogen synthase kinase-3 (GSK-3) has being identified as an ubiquitous serine-threonine protein kinase that participates in a multitude of cellular processes and plays an important role in the pathophysiology of a number of diseases. The aim of this study was to investigate the effects of GSK-3beta inhibition on the degree of arthritis caused by type II collagen (CII) in the mouse (collagen-induced arthritis; CIA). Mice developed erosive hind paw arthritis when immunized with CII in an emulsion in complete Freund's adjuvant (CFA). The incidence of CIA was 100% by day 28 in the CII-challenged mice and the severity of CIA progressed over a 35-day period with radiographic evaluation revealing focal resorption of bone. The histopathology of CIA included erosion of the cartilage at the joint margins. Treatment of mice with the GSK-3beta inhibitor TDZD-8 (1 mg/kg/day i.p.) starting at the onset of arthritis (day 25) ameliorated the clinical signs at days 26-35 and improved histological status in the joint and paw. Immunohistochemical analysis for nitrotyrosine, poly(ADP-ribose) (PAR), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) revealed a positive staining in inflamed joints from mice subjected to...Continue Reading

References

Dec 1, 1990·Immunological Reviews·R HolmdahlJ A Mo
May 26, 1993·Molecular and Cellular Biochemistry·D LautierG G Poirier
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C SzabóE Kun
Jul 25, 2000·Molecular Medicine Today·N L Carteron
Oct 2, 2001·Science's STKE : Signal Transduction Knowledge Environment·J R Woodgett
Nov 16, 2001·Current Rheumatology Reports·S B AbramsonR Clancy

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Citations

Sep 1, 2006·Neurochemical Research·Richard S JopeEléonore Beurel
Jun 9, 2007·American Journal of Respiratory and Critical Care Medicine·Zhang BaoW S Fred Wong
Nov 17, 2010·PloS One·Diana Aguilar-MoranteAna Perez-Castillo
Mar 27, 2007·Intensive Care Medicine·Salvatore CuzzocreaChristoph Thiemermann
Nov 20, 2013·Arthritis Research & Therapy·Daniela ImpellizzeriSalvatore Cuzzocrea
Apr 24, 2015·International Journal of Molecular Sciences·Chingju LinDah-Yuu Lu
Dec 2, 2014·Pharmacology & Therapeutics·Eleonore BeurelRichard S Jope
Oct 20, 2009·Trends in Immunology·Eléonore BeurelRichard S Jope
Dec 17, 2014·Translational Psychiatry·E Beurel, R S Jope
Aug 14, 2010·The Journal of Pain : Official Journal of the American Pain Society·Daniel F MartinsAdair R S Santos
Jan 13, 2017·Ocular Immunology and Inflammation·Shuo YangHong Lu
Jun 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tongxing WangYongxiang Zhang
May 16, 2007·Journal of Leukocyte Biology·Xiaoyu HuLionel B Ivashkiv
Apr 2, 2020·Cells·Leonie HoffmeisterRené Huber
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng-Chieh TsaiChiou-Feng Lin
Sep 21, 2007·International Journal of Immunopathology and Pharmacology·S CuzzocreaC Thiemermann
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrizia De SarnoRichard S Jope
Mar 19, 2015·The Journal of Pharmacology and Experimental Therapeutics·Igor A SchepetkinMark T Quinn
Aug 30, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng-Chieh TsaiChiou-Feng Lin
Mar 30, 2017·Experimental and Therapeutic Medicine·Prince Amoah BarnieHuaxi Xu
Jan 23, 2019·Frontiers in Pharmacology·Sorin HostiucEduard Drima
Jul 16, 2019·Rheumatology·Javier Fernández-TorresJosé M Rodríguez-Pérez

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