Glycogen synthesis in brain and astrocytes is inhibited by chronic lithium treatment

Neuroscience Letters
Andréa de Almeida SouzaM Montero-Lomelí

Abstract

Lithium is a drug widely used to treat bipolar disorder. It has been shown to inhibit the total activity of phosphoglucomutase (PGM) from rat brains. In this work, we show that lithium inhibits in vitro PGM activity in the cortex, hippocampus, striatum, brainstem and cerebellum. As a compensatory effect, chronic lithium treatment of Wistar rats for 6 weeks caused a 1.6-fold upregulation of cortex PGM activity. No difference was observed in the other areas tested. Another effect of chronic lithium administration was a drastic reduction of glycogen content in rat brains, as PGM activity is essential for its synthesis. In a primary culture of astrocytes, which are the main cellular components of the brain that produce glycogen, administration of 1mM lithium for 3 days markedly reduced the steady state of glycogen content. In agreement with this result, lithium did not cause insulin-like effects as previously observed in hepatocytes where lithium activated glycogen synthesis. Reduction of glycogen content was due to inhibition of glycogen synthesis, as incorporation of [(14)U(-)C]-glucose into glycogen was impaired by lithium. Consistent with these results, incubation of glucose-starved astrocytes with lithium did not stimulate dep...Continue Reading

References

Dec 1, 1981·Developmental Psychobiology·J J Franchina, S Dietz
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·N YuP J Magistretti
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S Klein, D A Melton
Jun 1, 1996·Brain Research. Molecular Brain Research·G PellegriJ L Martin
Feb 13, 2001·Biochemical and Biophysical Research Communications·W J Ryves, A J Harwood
Aug 14, 2001·The Journal of Biological Chemistry·C A MasudaM Montero-Lomeli
Dec 7, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nancy F Cruz, Gerald A Dienel
May 14, 2003·Neurochemistry International·Luc Pellerin
Jun 7, 2003·The Journal of Biological Chemistry·Christoffer BroJens Nielsen
Nov 2, 2005·The International Journal of Neuropsychopharmacology·Péter CsutoraAttila Miseta
Nov 30, 2006·American Journal of Physiology. Endocrinology and Metabolism·Gülin OzRolf Gruetter
Jan 17, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Montero-LomelíA E Nardi
Jul 31, 2007·Glia·Luc PellerinPierre J Magistretti
Jul 31, 2007·Glia·Angus M Brown, Bruce R Ransom
Jan 7, 2009·The Journal of Biological Chemistry·Susana RosJoan J Guinovart
May 7, 2009·Journal of Neurochemistry·Helle M SickmannHelle S Waagepetersen
May 30, 2009·Epilepsia·Nivetha RamachandranBerge A Minassian
Aug 28, 2009·Cell Biochemistry and Function·Eduardo KokubunHorst Haebisch
Sep 17, 2009·Biochemical Society Transactions·W Timothy O'Brien, Peter S Klein
Apr 29, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Helle M SickmannStephan D Bouman

❮ Previous
Next ❯

Citations

Feb 18, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Christos E Zois, Adrian L Harris
Jul 15, 2015·Biological Trace Element Research·D N SouzaJ Nicolau
Jan 7, 2016·Frontiers in Cellular Neuroscience·Maha Elsayed, Pierre J Magistretti
Jan 10, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ruud B van HeeswijkRolf Gruetter
Mar 26, 2016·Expert Review of Neurotherapeutics·Liang PengAlexei Verkhratsky
Jul 1, 2012·International Journal of High Risk Behaviors & Addiction·Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb
Jul 28, 2020·Biochimica Et Biophysica Acta. General Subjects·Álvaro Marín-HernándezEmma Saavedra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.