Glycogenolysis during short-term fasting in malaria and healthy subjects--the potential regulatory role of glycogen content on glycogen breakdown: a hypothesis

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
F SprangersH P Sauerwein

Abstract

During short-term starvation (< 24 h), glucose production decreases 10-20% due to a decrease in glycogenolysis. In the fed state glycogen regulates its rate of breakdown, in order to limit glycogen accumulation. Whether in the fasted state a similar mechanism exists to preserve glycogen content is not known. In malaria, the rate of glycogen breakdown after an overnight fast is considerably lower than in healthy subjects. If glycogen content regulates its rate of breakdown during fasting, we postulate that the rate of glycogenolysis should decrease faster in patients with malaria than in healthy subjects. In six non-severe falciparum malaria patients and 6 healthy controls glucose production with [6,6-2H2]-glucose, and glycogenolysis was calculated after measuring gluconeogenesis with the 2H2O-method between 16 and 22 h of fasting. Glucose production after 16 h of fasting was 15% higher in the malaria patients than in controls. Glycogenolysis in the malaria patients was 2.3 +/- 0.37 and 8.4 +/- 0.93 micromol/kg/min in the controls. The absolute decrease in glycogenolysis was slower in malaria patients than in controls (P = 0.001), whereas the relative decrease in glycogenolysis from baseline was not different. During fasting the...Continue Reading

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Citations

Mar 5, 2013·Journal of Nutrition in Gerontology and Geriatrics·Annabel J McDonald
Dec 30, 2014·Expert Review of Anti-infective Therapy·Lola MadridQuique Bassat
Jun 9, 2009·Metabolism: Clinical and Experimental·Wilco C W R ZijlmansHans P Sauerwein
Jun 7, 2005·Nursing Philosophy : an International Journal for Healthcare Professionals·Marc Roberts
Jul 3, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Wilco C W R ZijlmansHans P Sauerwein

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