Glycohemoglobin screening in adolescents attending to the Department of Paediatrics at a tertiary hospital in Turkey

Diabetes Research and Clinical Practice
Dilek DilliSabahat Gücük

Abstract

To investigate glycohemoglobin (HbAIc) levels in adolescents without diabetes, attending to our Adolescent Day Care Clinic. We studied on randomly selected 186 subjects aged between 9 and 18 years. HbA1c levels were measured in all subjects and those whose HbA1c levels >95th percentile were invited for oral glucose tolerance test (OGTT). Homeostasis of model assessment (HOMA-IR) value was used to define insulin resistance in subjects who underwent OGTT. The median age of all subjects was 11 (min 9-max 18) years and 50.5% were boys. The median HbA1c level was higher in boys (5.2%; min 4.4-max 6.2) than girls (5.0%; min 4.0-max 6.4) (p=0.001). Fasting glucose was positively correlated to HbA1c (r=0.26, p=0.001). HOMA-IR values were >2.5 in six subjects and four of them were obese while two had impaired glucose tolerance. In multivariate analysis, it was observed that gender (boy) and high-fasting glucose levels were associated with high-HbA1c levels (OR 1.9, CI 95%: 1.0-3.4, p=0.02 and OR 1.1, CI 95%: 1.0-1.1, p=0.001, respectively). We believe that routine HbA1c screening is not necessary for adolescents without diabetes. However screening may become desirable in the future at least for obese adolescents.

References

Jun 1, 1976·The Journal of Clinical Investigation·H F BunnP M Gallop
Jul 24, 1986·The New England Journal of Medicine·S A AmielW V Tamborlane
May 28, 2004·Diabetes Research and Clinical Practice·David J PettittLois Jovanovic

Citations

Aug 22, 2012·Endocrine·Trefor Higgins
Jun 19, 2012·Clinical Biochemistry·Trefor Higgins

Related Concepts

Blood Glucose
Cardiovascular Diseases
Diabetes Mellitus
Fasting
Intravenous Glucose Tolerance Test
Hb A1a-2
Medical History Taking
Adolescent Health Services

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