PMID: 9445397Mar 7, 1998Paper

Glycoinositol phospholipids from Endotrypanum species express epitopes in common with saccharide side chains of the lipophosphoglycan from Leishmania major

The Biochemical Journal
E Xavier Da SilveiraL Mendonça-Previato

Abstract

We have characterized glycoinositol phospholipids (GIPLs) from three strains of the trypanosomatid parasites Endotrypanum schaudinni and Endotrypanum monterogeii. Methanolysis of the intact GIPLs liberated methyl esters of tetracosanoic acid, docosanoic acid, octadecanoic acid and hexadecanoic acid and C20 and C21 phytosphingosines. Phosphoinositol oligosaccharides were released from the GIPLs by mild base treatment, and their structures were determined by compositional analysis, fast-atom-bombardment MS and NMR spectroscopy. Similar compounds were detected in all three strains, although their relative proportions varied. The predominant components in E. schaudinni strain LV59 and E. monterogeii LV88 were Galpbeta1-3Galpbeta1-3Manalpha1-3Manalpha1-4G lcNalpha1-6Ins-1-P and Arapbeta1-2Ga lpbeta1-3Galpbeta1-3Manalpha1-3Manalpha1-4Glc Nalpha1-6Ins-1-P, and the major phosphoinositol oligosaccharide in E. schaudinni LV58 was the hybrid-type GIPL Manalpha1-2(EtNP-6)Manalpha1-6(Galpbeta1-3Man alpha1-3)Manalpha1-4GlcN alpha1-6Ins-1-P (where EtNP is ethanolamine phosphate). Several minor oligosaccharides containing additional galactose and/or arabinose residues were also detected.

Citations

May 11, 1999·Journal of Cutaneous Pathology·J R KennerP Sau
Apr 29, 2008·Carbohydrate Research·Pauline PeltierVincent Ferrières
Sep 8, 2012·Molecular and Biochemical Parasitology·Mattie C Pawlowic, Kai Zhang
Aug 3, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Gregory SpanakosNicholas C Vakalis
Mar 2, 2017·Chembiochem : a European Journal of Chemical Biology·Katharina KolbeNorbert Reiling
Sep 24, 2011·Glycobiology·Boris TefsenFrançoise H Routier
May 4, 2017·The Journal of Biological Chemistry·Hongjie GuoStephen M Beverley
Mar 4, 2000·Archives of Biochemistry and Biophysics·F S BarrosJ R Meyer-Fernandes
Sep 7, 1999·Molecular and Biochemical Parasitology·M H BranquinhaM A Ferguson

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