Glycolaldehyde induces oxidative stress in the heart: a clue to diabetic cardiomyopathy?

Cardiovascular Toxicology
Rodrigo LorenziJosé Cláudio Fonseca Moreira

Abstract

Cardiovascular complications account for 80% of the mortality related to diabetes mellitus. Hyperglycemia is believed to be the major culprit of angiopathy and cardiomyopathy. High glucose levels and oxidative stress cause elevation of Advanced Glycation End-products that are known to contribute to diabetic complications and correlate with many diseases. However, there are few reports describing the effects of glycating agents other than glucose. Here, we aimed to evaluate the effects of glycolaldehyde (GA) on oxidative stress parameters in the heart of Wistar rats. Male Wistar rats received a single injection of GA (10, 50 or 100 mg/Kg) and were sacrificed 6, 12 or 24 h after injection. As indexes of oxidative stress, we quantified protein carbonylation, lipid peroxidation and total reduced thiols. The activities of superoxide dismutase, catalase and glyoxalase I were assayed. Also, the content of N (ɛ)-(carboxymethyl)lysine (CML) was quantified. Glycolaldehyde induced an imbalance in the redox status, with increased protein carbonylation and lipoperoxidation. Catalase and glyoxalase I had a decrease in their activities. Despite the oxidative stress, we observed no increase in CML content. These results suggest that short-chai...Continue Reading

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Citations

Nov 10, 2011·Clinical and Experimental Pharmacology & Physiology·Ethan J AndersonMonte S Willis
Feb 26, 2014·BMC Systems Biology·Limin LiVassilios S Vassiliadis
Mar 8, 2011·International Journal of Toxicology·Rodrigo LorenziJosé Cláudio Fonseca Moreira
Dec 18, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasushi TeshimaTetsunori Saikawa
Oct 15, 2020·International Journal of Molecular Sciences·Micaela GliozziVincenzo Mollace

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