Abstract
Walnut meal (WM) is rich in polyphenols which exhibit multiple therapeutic effects. The purpose of this study was to investigate the therapeutic effects of walnut meal extracts (WMP) on glycolipid metabolism and liver transcriptomics in T2DM rats. A T2DM rat model was established by using a high-fat diet combined with streptozotocin. A 5-week WMP therapy showed the effects of decreasing water intake, excretion, fasting blood glucose, fasting insulin, and insulin resistance, increasing β-cell function and insulin sensitivity index; meanwhile regulating dysfunctional lipid metabolism and reducing inflammation; improving body weight, oral glucose tolerance test and insulin sensitivity; and increasing the activities of SOD and CAT while decreasing the MDA levels in the liver and serum of T2DM rats. Moreover, 10 key differentially expressed genes were identified by RNA-seq, including Gck, RT1-Ba, Fasn, Slc13a3, Cd74, Jun, Cyp4a1, Myh7b, Plin3, and Got1, and they were highly potentially related to glycolipid metabolism. Our results suggested that WMP exhibited the anti-diabetic effect and could regulate glycolipid metabolism in T2DM rats. This finding might assist in identifying potential therapeutic targets for T2DM prevention and i...Continue Reading
References
Nov 25, 2000·Metabolism: Clinical and Experimental·M J ReedG M Reaven
Jul 3, 2002·Annals of Internal Medicine·Dmitri KirpichnikovJames R Sowers
Oct 13, 2006·Journal of Agricultural and Food Chemistry·Li LiJ Christopher Young
Jun 13, 2012·Journal of Ethnopharmacology·Liangcai ZhaoDonghai Lin
Aug 15, 2012·Diabetes Care·Jamie MortonUNKNOWN ADVANCE Collaborative Group
May 8, 2013·British Journal of Pharmacology·Wei WangLing-Dong Kong
Jun 19, 2013·Journal of Chemical Information and Modeling·Sheng TianTingjun Hou
Aug 31, 2013·PloS One·Xiaolong KangMeiying Fang
Jun 11, 2014·BMC Complementary and Alternative Medicine·Qian ZhangJia Zheng
Jun 30, 2016·International Journal of Food Sciences and Nutrition·Ying ZhuYing Dong
Aug 2, 2016·Journal of Diabetes Research·M KnaśA Zalewska
Sep 24, 2016·Diabetes Care·Zahra AryanAlireza Esteghamati
Sep 30, 2016·Scientific Reports·Yuhuan MengXiaoning Wang
Mar 5, 2017·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hongli YanJie Yu
Jul 26, 2017·Pharmaceutical Biology·Yan LuoShenglan Zhao
Nov 29, 2017·Journal of Diabetes Research·Bingdi YanJunling Yang
Mar 7, 2018·PeerJ·Qian ZhangXiaobing Yu
Apr 28, 2018·International Journal of Biological Macromolecules·Guimei LiuQuanhong Li
Jun 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Valeria RodríguezNori Tolosa de Talamoni
Sep 6, 2018·Gene·Weiqi BaiHongman Chen
Oct 31, 2018·Frontiers in Endocrinology·Dan TangHaji Akber Aisa
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yimin YinZhuoqin Jiang
Feb 27, 2019·Journal of Ethnopharmacology·Chang-Hua ZhangLi-Fen Zhou
Mar 29, 2019·Food Science & Nutrition·Ji LiuShenglan Zhao
May 17, 2019·Food & Function·Jie TuHang Xiao
May 31, 2019·Genes·Wenlu ZhangHongli Du
Jun 8, 2019·Chemico-biological Interactions·Sahar A KhaleelAdel R Abd-Allah
Aug 11, 2019·Redox Biology·Lixiao ZhangHong Wang
Oct 4, 2019·PeerJ·Shuying FuHongli Du
Oct 7, 2019·Journal of Ethnopharmacology·Yulong ZhangXiaobo Li
Oct 14, 2019·Archives of Toxicology·Yangyang DingXiangyang Wu
Nov 9, 2019·Diabetes & Metabolism Journal·Young Joo KimDoo Man Kim
Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qian GuoLirong Wu
Nov 20, 2019·Wiener klinische Wochenschrift·Nawras Al-TaieHarald Stingl
Mar 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yuichi NozakiGerald I Shulman