PMID: 6988675Jan 1, 1980Paper

Glycolytic enzymes and intermediates in carbon catabolite repression mutants of Saccharomyces cerevisiae

Molecular & General Genetics : MGG
K D Entian, F K Zimmermann

Abstract

Glycolytic parameters were determined in recessive yeast mutants with partial defects in carbon catabolite repression. Specific activities of pyruvate kinase and pyruvate decarboxylase in glucose grown cells of all mutant and wild type strains were 4--5 times higher than in ethanol grown cells. Mutants of gene HEX1 had a reduced hexose phosphorylating activity on all media whereas those of gene HEX2 had elevated levels but only in glucose grown cells. Mutants of gene CAT80 were normal in this respect. All other glycolytic enzymes were normal in all mutants. This was also true for glycolytic intermediates. Only hex1-mutants showed a reduced fermentation of repressing sugars. The three genes appear to be involved in catabolite repression of several but not of all repressible enzymes. Even though all three types of mutants show a limited overlap in their effects on certain enzymes, they still are distinctly different in their action spectra. Carbon catabolite repression apparently does not depend on the sole accumulation of glycolytic intermediates. The activity of the products of the three genes HEX1, HEX2 and CAT80 are required directly or indirectly for triggering carbon catabolite repression. Even a small segment of carbon cat...Continue Reading

References

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Citations

Oct 5, 1996·Biotechnology and Bioengineering·K van Dam
Dec 1, 1988·Molecular & General Genetics : MGG·J B GreenB S Hartley
Apr 1, 1992·Current Genetics·K Melcher, K D Entian
Jan 1, 1984·Molecular & General Genetics : MGG·K U FröhlichD Mecke
Aug 1, 1989·Current Genetics·V M PaschoalinA D Panek
Sep 1, 1984·Current Genetics·A K McCann, J A Barnett
Mar 1, 1987·Molecular & General Genetics : MGG·D Niederacher, K D Entian
Jan 1, 1983·Biotechnology Advances·R Hütter, P Niederberger
Dec 1, 1992·Trends in Biochemical Sciences·K D Entian, J A Barnett
Jan 1, 1995·Trends in Genetics : TIG·H Ronne
Oct 18, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yan XuAdalberto Pessoa
Aug 1, 1997·Molecular Biology of the Cell·M J De VitM Johnston
Sep 1, 1991·European Journal of Biochemistry·D Niederacher, K D Entian
Jun 1, 1992·European Journal of Biochemistry·J M Gancedo
Apr 19, 2003·FEMS Yeast Research·D EschrichK-D Entian
Apr 3, 2001·Applied and Environmental Microbiology·J A DiderichK Van Dam
Mar 10, 2006·Microbiology and Molecular Biology Reviews : MMBR·George M Santangelo
Jan 1, 1986·CRC Critical Reviews in Biochemistry·S D HanesK A Bostian
Jan 1, 1990·Critical Reviews in Biochemistry and Molecular Biology·C Wills
Sep 1, 1994·European Journal of Biochemistry·S OzcanM Ciriacy
Sep 1, 2005·Yeast·James A Barnett, Karl-Dieter Entian
Jun 19, 2008·FEMS Microbiology Reviews·Juana M Gancedo
Apr 19, 2003·FEMS Yeast Research·Filip RollandJohan M Thevelein
Feb 22, 2007·FEMS Yeast Research·Mónica M Belinchón, Juana M Gancedo
Aug 3, 2016·FEMS Yeast Research·Akshay VishwanathaMartin Ernst Schweingruber

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