Glycopolymers Mimicking GM1 Gangliosides: Cooperativity of Galactose and Neuraminic Acid for Cholera Toxin Recognition

Chemistry, an Asian Journal
Yuhei TeradaYoshiko Miura

Abstract

Glycopolymers mimicking GM1 gangliosides were synthesized by incorporating multiple types of carbohydrates into the polymer backbone. The glycopolymers were immobilized onto gold surfaces, and the interactions with the cholera toxin B subunit (CTB) were analyzed using surface plasmon resonance imaging. The glycopolymer containing both galactose and neuraminic acid showed enhanced recognition of CTB. The interaction was enhanced mainly because of an improvement in the dissociation process by the binding of the neuraminic acid group in the GM1 binding pocket. This cooperativity of galactose and neuraminic acid was achieved by incorporation into the same flexible polymer backbone, and the importance of the close placement of galactose and neuraminic acid groups was revealed. These results will be valuable in medical fields and also for the development of biofunctional materials.

References

Aug 25, 1995·Journal of Molecular Biology·R G ZhangE M Westbrook
Feb 1, 1994·Protein Science : a Publication of the Protein Society·E A MerrittW G Hol
Jun 6, 2003·Journal of the American Chemical Society·Emily A SmithRobert M Corn
Jan 30, 2004·Journal of the American Chemical Society·W Bruce TurnbullSteve W Homans
Mar 18, 2005·Journal of the American Chemical Society·Daniela ArosioRocco Ungaro
Jun 3, 2005·Nature Reviews. Drug Discovery·Danielle H Dube, Carolyn R Bertozzi
Apr 6, 2006·Journal of the American Chemical Society·Vincent LadmiralDavid M Haddleton
Jul 12, 2008·Chemistry : a European Journal·Anne ImbertyRené Roy
Jun 9, 2009·Chemical Communications : Chem Comm·Tomonari TanakaShin-Ichiro Shoda
Jun 13, 2015·Natural Product Reports·You YangBiao Yu
Oct 29, 2015·Chemical Reviews·Yoshiko MiuraHirokazu Seto
Oct 16, 2016·Biomacromolecules·Samantha J PaluckHeather D Maynard
Jul 12, 2017·Macromolecular Rapid Communications·Yamin AbdouniC Remzi Becer
Dec 28, 2017·Chemical Reviews·Kei KitamuraKeisuke Suzuki
Dec 29, 2017·Chemistry : a European Journal·Gao-Lan Zhang, Xin-Shan Ye

❮ Previous
Next ❯

Citations

Apr 24, 2020·Chemical Communications : Chem Comm·Manuel González-CuestaJosé M García Fernández
May 19, 2021·Biochemical and Biophysical Research Communications·Hiroyuki KoideTomohiro Asai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.