GlycoProfileAssigner: automated structural assignment with error estimation for glycan LC data

Bioinformatics
Fergal J Duffy, Pauline M Rudd

Abstract

Sequencing glycan structures is a difficult problem that requires the use of multiple experimental approaches. One powerful approach to glycan sequencing is the combination of liquid chromatography with sequential exoglycosidase digestions; however, interpreting this can be difficult and time-consuming. To aid this process, we introduce GlycoProfileAssigner, software for automated structural assignment of glycan profile data from liquid chromatography experiments. GlycoProfileAssigner has been tested on human IgG data, and can retrieve the correct structure in 14 out of 16 peaks tested. The programme and its source code is available at https://bitbucket.org/fergaljd/glycoprofileassigner : pauline.rudd@nibrt.ie Supplementary data are available at Bioinformatics online.

References

May 21, 2005·The Journal of Organic Chemistry·Chi-Huey Wong
Oct 13, 2006·Nature Biotechnology·Gary Walsh, Roy Jefferis
Mar 18, 2008·Bioinformatics·Matthew P CampbellPauline M Rudd
Sep 1, 2011·Analytical and Bioanalytical Chemistry·Bogusław Buszewski, Sylwia Noga

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