PMID: 6163576Sep 1, 1980Paper

Glycoprotein hormone alpha subunit secretion by pituitary adenomas: influence of external irradiation

Clinical Endocrinology
I A MacFarlaneM L Sutton

Abstract

In ninety-nine patients with pituitary adenomas, forty-six with acromegaly, the serum level of the glycoprotein hormone alpha subunit was elevated in eighteen cases. Thirteen of these were acromegalic and one had an FSH-producing tumour. Alpha levels varied little during the day, from one day to the next and over a 6 month period. In twenty-five patients with a variety of other hypothalamic-pituitary disorders examined, one patient with a craniopharyngioma had a mildly elevated alpha level. External pituitary irradiation was followed by an acute and often transient fall in alpha level in several of these patients. Of the fifty-four patients with pituitary adenomas who had received external irradiation before testing, only five had elevated alpha subunit levels compared with thirteen patients of the forty-five who had not been irradiated. This difference in incidence of elevated alpha level was statistically significant (P less than 0.025). We conclude that external irradiation may reduce alpha subunit level chronically in many patients with pituitary adenoma.

References

Apr 1, 1979·The Journal of Clinical Endocrinology and Metabolism·R C SmallridgeR C Dimond
Jun 1, 1979·The Journal of Clinical Endocrinology and Metabolism·R C EastmanJ Roth
May 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Dosogne-GuérinA Borkowski
Jul 1, 1976·The Journal of Clinical Endocrinology and Metabolism·I A KouridesF Maloof
Mar 1, 1977·The Journal of Clinical Investigation·I A KouridesF Maloof
May 1, 1975·The Journal of Clinical Endocrinology and Metabolism·I A KouridesF Maloof

❮ Previous
Next ❯

Citations

Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·M E Shomali, L Katznelson
Apr 1, 1995·Baillière's Clinical Endocrinology and Metabolism·M H Samuels, E C Ridgway
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·A M Landolt, P U Heitz
Oct 1, 1983·Journal of Neurosurgery·A KlibanskiN T Zervas
Feb 1, 1994·Clinical Endocrinology·J P Monson
May 21, 1981·The New England Journal of Medicine·E C RidgwayN T Zervas
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C OliveiraJ G Vieira
Jan 1, 1981·Neurosurgical Review·S H NyströmK K Tulkki
Jul 21, 1999·Journal of Neurosurgery·M F PhilipsR W Hurst
Apr 1, 1984·Journal of Neurosurgery·C Sainte-RoseJ F Hirsch
May 15, 2003·Journal of Neurosurgery·Brian K OwlerMichael Besser
Jan 1, 1985·Neurosurgical Review·R Fahlbusch, M Buchfelder
Nov 3, 2009·Neurosurgical Focus·Maryam RahmanJ Mocco
Jan 1, 1981·Acta neurochirurgica·E R Hitchcock, R A Cowie
Apr 19, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R Hayward
Oct 1, 1987·Histopathology·A M McNicol
May 1, 1990·Journal of Endocrinological Investigation·G Giannattasio, M Bassetti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.