Glycoprotein levels and oxidative lung injury in experimental diabetes: effect of oxovanadium(IV) complex based on thiosemicarbazone.

Toxicology Mechanisms and Methods
Bertan Boran BayrakRefiye Yanardag

Abstract

Diabetes mellitus (DM) is chronic and metabolic disorder, which is mainly attributed by hyperglycemia. Vanadium salts and their oxo-complexes have been shown to possess insulin-mimetic and anti-diabetic activities in animal models and diabetic patients. The main goal of this study was to investigate the protective effect of oxovanadium(IV) complex based on thiosemicarbazone (VOL) [L: (N(1)-2,4-dihydroxybenzylidene-N-(4)-2-hydroxybenzylidene-S-methyl-isothiosemicarbazidato-oxovanadium(IV)] on glycoprotein components levels and oxidative lung injury of streptozotocin (STZ)-induced diabetic rats. Male Swiss albino rats were separated into four groups. Group I (n = 5): Control (normal) animals, Group II (n = 5): Control animals administered with VOL, Group III (n = 6): STZ-induced diabetic animals, and Group IV (n = 5): STZ-induced diabetic rats treated with VOL. VOL was given to the experimental animals by gavage at a dose of 0.2 mM/kg body weight every day for 12 days. Diabetes was induced by single intraperitoneal injection of STZ (65 mg/kg body weight). On the 12th day, lung tissue samples were taken. Glycoprotein components, advanced oxidation protein products, protein carbonyl, hydroxyproline levels, and prolidase, arginase, ...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·R L LevineE R Stadtman
Jul 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·T KondoY Kawakami
Dec 1, 1969·The American Journal of Physiology·A S Ridderstap, S L Bonting
Feb 1, 1971·Analytical Biochemistry·J W Geyer, D Dabich
Jan 1, 1984·Methods in Enzymology·H Aebi
Jan 1, 1981·Methods in Enzymology·A Wendel
Jan 1, 1981·Methods in Enzymology·W H Habig, W B Jakoby
May 1, 1996·Kidney International·V Witko-SarsatB Descamps-Latscha
Jun 1, 1996·Clinical Biochemistry·G K Reddy, C S Enwemeka
Jul 8, 2000·Journal of Inorganic Biochemistry·D C Crans
Jan 1, 1964·Scandinavian Journal of Clinical and Laboratory Investigation·H KARKER
Jan 1, 1955·Methods of Biochemical Analysis·R J WINZLER
Feb 4, 2006·Cell Biochemistry and Biophysics·Mohamad Z MehdiAshok K Srivastava
Jan 29, 2008·European Journal of Medicinal Chemistry·Renata B de OliveiraCarlos L Zani
Apr 26, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Harm MaarsinghHerman Meurs
Dec 3, 2010·Journal of Medicinal Chemistry·Giorgio PelosiElisabetta Pilotti
Nov 22, 2011·Metallomics : Integrated Biometal Science·Eswaran RamachandranKaruppannan Natarajan
Mar 8, 2013·European Journal of Medicinal Chemistry·Subramanian Iyyam PillaiMuthusamy Kandaswamy
Aug 29, 2013·Metallomics : Integrated Biometal Science·Gail R WillskyPaul J Kostyniak
Oct 16, 2013·Chemico-biological Interactions·Luciana G NasoPatricia A M Williams
Dec 4, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Tülay Bal-DemirciReşat Apak
Apr 22, 2015·Molecular and Cellular Biochemistry·B KaločayováN Vrbjar
Jan 29, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ozlem SacanRefiye Yanardag
Feb 6, 2016·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·E OzgunE Cakır
May 18, 2016·Pharmaceutical Biology·Guilherme F CaetanoMarco Andrey Cipriani Frade
Jun 18, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Margery A ConnellyRobin P F Dullaart
Jul 16, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·José L Domingo, Mercedes Gómez
Dec 13, 2016·The Biochemical Journal·Philip NewsholmePaulo Ivo Homem de Bittencourt
Jan 5, 2017·Enzyme Research·Bagher LarijaniReza Saghiri
Mar 23, 2017·BMJ Open Diabetes Research & Care·Lokendra Bahadur SapkotaNuwadatta Subedi
Nov 8, 2017·Journal of Inherited Metabolic Disease·Markus Hecker, Andreas H Wagner
May 10, 2018·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Ali Asghar HemmatiAkram Ahangarpour

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